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30 results about "Vascular anomaly" patented technology

A vascular anomaly is a kind of birthmark caused by a disorder of the vascular development, although it is not always present at birth. A vascular anomaly is a localized defect in blood vessels that can affect each part of the vasculature (capillaries, arteries, veins, lymphatics or a combination of these). These defects are characterized by an increased number of vessels and vessels that are both enlarged and sinuous. Some vascular anomalies are congenital and therefore present at birth, others appear within weeks to years after birth and others are acquired by trauma or during pregnancy. Inherited vascular anomalies are also described and often present with a number of lesions that increase with patients’ age. Vascular anomalies can also be a part of a syndrome and, occasionally, they can be acquired by trauma. The estimated prevalence of vascular anomalies is 4.5%. Vascular anomalies can occur throughout the whole body (skin, bone, liver, intestines, i.e.), but in 60% of patients vascular anomalies are localized in the head and neck region. Vascular anomalies can present in various ways. Vascular anomalies that are situated deep below the skin, appear blue and are often called cavernous. Superficial vascular anomalies appear as red-coloured stains and are associated with vascular anomalies affecting the dermis. Historically, vascular anomalies have been labeled with descriptive terms, according to the food they resembled (port wine, strawberry, cherry, salmon patch). This imprecise terminology has caused diagnostic confusion, blocked communication and even caused incorrect treatment, as it does not differentiate between various vascular anomalies. However, in 1982, Mulliken introduced a classification that replaced these descriptive terms and gave direction to the management of various vascular anomalies. This classification, based on clinical features, natural history and cellular characteristics, divides vascular anomalies into two groups: vascular tumors and vascular malformations. Although the appearance of both vascular tumors and vascular malformations can resemble, there are important differences between both.

Magnetic product for refining molecular groups of both blood and water in body and application thereof

The invention relates to a magnetic product for refining molecular groups of both blood and water in a body and application thereof. The intensity of magnetism of the product adopting a magnetic material is in the range of equal to or larger than 2000 gausses. The product adopting the magnetic material provided by the invention has the advantages that the molecular groups of both blood and water in the body can be refined; the condensation of red blood cells is avoided; the effect of activating blood and dissolving stasis is achieved; the blood viscosity can be reduced; the vascular anomaly (such as sclerosis, rhexis and lumen stenosis) and cardiac anomaly (such as reducing of mental and physical efforts) can be avoided; the ability of the blood for providing oxygen and nutriment and the ability of the blood for discharging metabolic products, such as carbon dioxide, are increased; and the product adopting the magnetic material is particularly suitable for middle-aged and elderly people with fast pace of work, high pressure and declining immune functions, and can be used for preventing and treating high blood pressure, cervical spondylosis, hand and foot numbness, arthralgia, scapulohumeral periarthritis, migraine, early rheumatoid arthritis, early vitiligo, chloasma, age pigment, poor circulation of vital energy and blood, cerebral infarction, myocardial infarction and the like.
Owner:张志伟

Treatment of skin disorders

ActiveUS11414426B2Improved profileLower immunosuppressive potentialOrganic active ingredientsOrganic chemistryMetaboliteThio-
The present invention relates to a compound of formula (I), wherein X1, X2 and X3 are, independently of each other, N or CH; with the proviso that at least two of X1X2 and X3 are N; Y is N or CH; W is H or F; with the proviso that when W is F, then Xi, X2 and X3 are N; R1 and R2 are independently of each other (i) a morpholinyl of formula (II) wherein the arrow denotes the bond in formula (I); and wherein R3 and R4 are independently of each other H, C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalkyl, C1-C2alkoxy, C1-C2alkoxyC1-C3alkyl, CN, or C(O)O—C1-C2alkyl; or R3 and R4 form together a bivalent residue —R5R6— selected from C1-C3alkylene optionally substituted with 1 to 4 F, —CH2—O—CH2—, —CH2—NH—CH2—, or any of the structures wherein the arrows denote the bonds in formula (II); or (ii) a saturated 6-membered heterocyclic ring Z selected from thiomorpholinyl and piperazinyl, optionally substituted by 1 to 3 R7; wherein R7 is independently at each occurrence C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalkyl, C1-C2alkoxyC1-C3alkyl, C3-C6cycloalkyl; or two R7 substituents form together a bivalent residue —R8R9— selected from C1-C3alkylene optionally substituted with 1 to 4 F, —CH2—O—CH2— or —O—CH2CH2—O—; with the proviso that at least one of R1 and R2 is a morpholinyl of formula II; and prodrugs, metabolites, tautomers, solvates and pharmaceutically acceptable salts thereof, for use in a method of treating a skin disorder in a subject, wherein said skin disorder is a genodermatosis, a vascular anomaly or a skin disorder selected from scleroderma, sclerodermatous chronic graft-versus-host disease, lichen sclerosus, lichen planus, lichen ruber planus and scars.
Owner:TORQUR AG

Treatment of skin disorders

The present invention relates to a compound of formula (I), wherein X<1>, X<2> and X<3> are, independently of each other, N or CH; with the proviso that at least two of X<1>, X<2> and X<3> are N; Y isN or CH; W is H or F; with the proviso that when W is F, then X<1>, X<2> and X<3> are N; R<1> and R<2> are independently of each other (i) a morpholinyl of formula (II) wherein the arrow denotes thebond in formula (I); and wherein R<3> and R<4> are independently of each other H, C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalkyl, C1-C2alkoxy, C1-C2alkoxyC1-C3alkyl, CN, or C(O)0-C1- C2alkyl; or R<3> and R<4> form together a bivalent residue -R<5>R<6>- selected from C1-C3alkylene optionally substituted with 1 to 4 F, -CH2-0-CH2-, -CH2-NH-CH2-, or any of the structures wherein the arrows denote the bonds in formula (II); or (ii) a saturated 6-membered heterocyclic ring Z selected from thiomorpholinyl and piperazinyl, optionally substituted by 1 to 3 R<7>; wherein R<7> isindependently at each occurrence C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalkyl, C1- C2alkoxyC1-C3alkyl, C3-C6cycloalkyl; or two R<7> substituents form together a bivalent residue -R<8>R<9>- selected from C1-C3alkylene optionally substituted with 1 to 4 F, -CH2-0-CH2- or -0- CH2CH2-0-; with the proviso that at least one of R<1> and R<2> is a morpholinyl of formula II; andprodrugs, metabolites, tautomers, solvates and pharmaceutically acceptable salts thereof, for use in a method of treating a skin disorder in a subject, wherein said skin disorder is a genodermatosis,a vascular anomaly or a skin disorder selected from scleroderma, sclerodermatous chronic graft-versus-host disease, lichen sclerosus, lichen planus, lichen ruber planus and scars.
Owner:TORQUR AG
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