41results about How to "Delay Elimination" patented technology

A cyclic dinucleotide compound of Formula (I):

wherein X₁ is H or F; X₂ is H or F; at least one among X₁ and X₂ is a fluorine atom; Z is OH, OR₁, SH or SR₁, wherein: R₁ is Na or NH₄, or R₁ is an enzyme-labile group which provides OH or SH in vivo such as pivaloyloxymethyl; B₁ and B₂ are bases chosen from Adenine, Hypoxanthine or Guanine, and B₁ is a different base than B₂ and a pharmaceutically acceptable salt thereof. Pharmaceutical compositions including the cyclic dinucleotide, as well as their use in the treatment of a bacterial infection, a viral infection or a cancer are also described.

The present inventors discovered that incorporating an Fc region and an antigen-binding domain whose antigen-binding activity varies depending on ion concentration into an antigen-binding molecule that binds to an aggregate-forming antigen produces an antigen-binding molecule that can preferentially clear protein aggregates in comparison to protein monomers from plasma. Use of antigen-binding molecules of the present invention allows various diseases stemming from target tissues to be treated target-tissue-specifically. Use of antigen-binding molecules of the present invention enables treatment of diseases caused by protein aggregates.

The invention discloses a method, a device and a system for recording a song audio and belongs to the technical field of computers. The method comprises steps of: sending an accompaniment audio to a Bluetooth device through an accompaniment channel and sending a time sequential value to the Bluetooth device through a data channel according to a preset period; receiving a human voice audio sent by the Bluetooth device through a human voice channel and receiving a first time sequential value sent by the Bluetooth device through the data channel, wherein the first time sequential value is the time sequential value received when the Bluetooth device begins to play the accompaniment audio; and according to a second time sequential value sent when the accompaniment audio is begun to be sent to the Bluetooth device, and the first time sequential value, carrying out audio mixing on the accompaniment audio and the received human voice audio so as to obtain the sound audio. By use of the method, the device and the system, synchronization degree of the accompaniment audio and the human voice audio can be increased.

The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH₂) CH₃ or CH(CH₃)₂; R₂ together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R₃ or R₄ are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R₃ and R₄ are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R₁ is zero when Y is O, and R₁ is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.

The invention relates to a non-invasive detection system and method for automatic neuropathy. The non-invasive detection system comprises an electrode array, a voltage reference module, a switch array, a measuring module, an adjustable resistor, a discrete voltage module, a central processing unit, an analysis module and the like. The method comprises the steps of using the adjustable precision resistor for achieving human body resistance changes and an equivalent resistance of a capacitance effect after a human body resistance and the equivalent resistance of the capacitance effect; then, determining an access to be tested; after voltages of two poles of an electrode and the voltage of the adjustable precision resistor in a circuit are tested and stored, processing data to generate I-U curve charts so as to obtain a group of slope data; and performing automatic neuropathy feature analysis through comparison of a pathology database according to the slope data to obtain the pathology condition to which a subject belongs, and outputting results.

A checkout counter belt cover for displaying information, including advertising information. The cover is formed of a stretchable material and includes at least one printable surface. The cover is releasably attachable to a checkout counter belt such that it substantially covers the entire belt but without affecting standard belt movement. A perimeter attachment component and a width attachment component are removably affixed to the belt. One end of the cover is releasably affixed to the width attachment component. As the belt is moved, the cover is releasably affixed to the perimeter attachment component. As one rotation of the belt is completed, the opposite end of the cover is releasably affixed to the width attachment component adjacent to the one end of the cover.

A kit for caring for a fabric article includes multiple products such as a fabric treatment composition and a laundry detergent composition, a fabric conditioning composition, and/or a second fabric treatment composition. Each of the multiple products contains a coordinated element, such as a brand name, a characteristic ingredient, container graphics, containers, dosages per container, a dye, a perfume, a trade dress, a set of usage instructions, and a combination thereof.

An image processor used in digital camera unit, includes a LCD interface connected with LCD module, the image processor can implement controlling the LCD module and data transmitting with LCD module through this LCD interface. The channel formed between LCD interface and host interface of connecting module of host machine is a transparent channel, the host machine module is connected with LCD module ; the said image processor also includes a independent MCU (micro control unit), when this image processor is used in a independent digital camera, this MCU can be a replacement of main control unit in host machine. It also can used in the mobile communication terminal with video capture, and no need to take a big change.

A high flux X-ray tube anode target assembly (101). The assembly includes a support shaft (107) connected to a pivot assembly (109). The assembly further includes a movable anode target (105) having a target surface (106) disposed at one end of the support shaft. The target surface includes a single radius of curvature. The radius of curvature extends from a pivot point (110). The assembly also includes a drive member (119) operably arranged with respect to the support shaft to provide motion to the anode target. The assembly is configured to maintain a substantially fixed distance between the pivot point and the target surface.

An X-ray tube anode target assembly (101) having a support shaft (107) connected to a pivot assembly (109) and a movable anode target (105) having a target surface (106) disposed at one end of the support shaft and a contact element (108) disposed at the opposite end of the support shaft. A first drive assembly (115) is operably arranged with respect to the support shaft to provide oscillatory motion to the anode target about a first axis substantially parallel to the support shaft and a drive cylinder (125) is operably arranged with respect to the contact element to provide a pivoting motion to the support shaft. A second drive assembly (127) is operably arranged with respect to the drive cylinder to provide an oscillatory motion to the drive cylinder, the second drive cylinder being further configured to provide a linear motion parallel to the first axis. The target surface is maintained at a substantially constant angle of impingement and maintains a substantially fixed distance from a cathode (103) during target motion.

The invention discloses a diverter valve integrated with a waterway switch, a waterway control method and a cleaning waterway. The diverter valve comprises a valve element, a valve seat and a rotary driving part, a plurality of water outlets communicated with water use channels are formed in the end face, making contact with the valve element, of the valve seat, water passing holes communicated with a water inlet are formed in the end face, making contact with the valve seat, of the valve element, and the rotary driving part drives the valve element to rotate relative to the valve seat; and the water outlets and the water passing holes are distributed in a circular ring with the relative rotation center as the circle center, a blocking piece used for blocking the water inlet when the valve element rotates to the set position where the water passing holes and the water outlets are not communicated is further included, and the blocking piece and the valve element rotate synchronously. The diverter valve has the advantages of being simple in structure, flexible and convenient to adjust, integrated in function and the like; the waterway control method has the advantages of being high in adjusting sensitivity, eliminating the delay phenomenon, optimizing the use feeling of a user and the like; and the cleaning waterway has the advantages of being high in stability, obvious in cost optimization and the like.

The present disclosure provides engineered human extracellular DNASE proteins (e.g., variants of DNASE1 (D1), DNASE1-LIKE 1 (D1L1), DNASE1-LIKE 2 (D1L2), DNASE1-LIKE 3 Isoform 1 (D1L3), DNASE1-LIKE 3 Isoform 2 (D1L3-2), DNASE2A (D2A), and DNASE2B (D2B)) that are useful for treating conditions characterized by neutrophil extracellular trap (NET) accumulation and/or release. In accordance with the invention, the DNase variant has advantages for therapy and/or large-scale manufacturing.

The invention relates to aqueous solution pharmaceutical compositions comprising at least one non-ionic tonicity agent, at least one buffer and an active ingredient, wherein said active ingredient is a compound of formula I, wherein R¹-R⁹ are defined herein; processes for preparing these compositions and their use in medicine, especially their use in the treatment of ocular diseases.