Ultra-high toughness, excellent weldability HT550 steel plate and its manufacturing method, based on the composition system of ultra-low C-high Mn-Nb microalloying-ultrafine Ti treatment, controlling Mn / C at 15-30, (%Si) ×(%Ceq)≤0.050, (%C)×(%Si)≤0.010, (%Mo)×[(%C)+0.13(%Si)] at 0.003~0.020, Ti / N=2.0~4.0, (Cu+Ni+Mo) alloying, Ni / Cu≥1.0, Ca treatment, Ca / S ratio between 0.80 and 3.00, by optimizing the TMCP process, the microstructure of the steel plate is fine ferrite + self-tempered bainite , the average grain size is less than 15μm, the yield strength is ≥460MPa, the tensile strength is 550MPa~700MPa, the yield ratio is ≤0.85, and the Charpy impact energy (single value) at -60°C is ≥60J; in obtaining uniform and excellent toughness and strong plasticity While matching, the steel plate can withstand large heat input welding, especially suitable for cross-sea bridge structures, offshore wind tower structures, offshore platform structures and hydropower structures.