The invention discloses a seamless flux cored wire with good vertical position welding manufacturability, and relates to the field of welding materials. The seamless flux cored wire is composed of low carbon steel outer skin and flux core powder, and the flux core powder is prepared from the mixing of materials, by mass, 35%-50% of rutile, 2%-4% of dehydrated feldspar, 4%-6% of aluminum magnesium alloy, 2%-3% of ferrotitanium, 9%-14% of low carbon ferromanganese, 1%-2% of zircon sand, 3%-8% of aluminum oxide, 4%-6% of quartz, 0.5%-1% of sodium fluoride and the balance iron powder. According to the seamless flux cored wire with the good vertical position welding manufacturability, the flux core powder is added online synchronously, after the flux core powder is added into the outer skin steel belt, the outer skin steel belt is then subjected to rolling forming and welding seaming, and afterwards subjected to annealing, reducing and copper plating so that the seamless flux cored wire can be prepared. The prepared seamless flux cored wire is stable in mechanical property, low in diffusible hydrogen, high in moisture absorption performance, excellent in antirust performance, and good in welding manufacturability; meanwhile, all-position welding can be conducted, the seamless flux cored wire is particularly applicable to welding of position of vertical welding, and can be used for welding of a D36 level steel plate.