The invention relates to design of a high-manganese medium-thickness plate applied to LNG (Liquefied Natural Gas) storage tanks and a production method thereof and belongs to the field of steel materials. The high-manganese medium-thickness plate comprises the following chemical components in percentage by weight: 0.45-0.67% of C, 0.02-0.48% of Si, 23.70-27.20% of Mn, less than or equal to 0.051% of P, less than or equal to 0.02% of S, 0.00-2.20% of Ni, 0.00-4.13% of Cr, 0.00-1.10% of Cu, 0.00-0.94% of Mo, 0.00-0.21% of V, 0.00-4.64% of Al and the balance of Fe and inevitable impurities. The production method of the high-manganese medium-thickness plate comprises the steps of smelting, pouring, forging and rolling. The product obtains a single-phase austenite structure; the experiment steel has high plasticity, simultaneously obtains excellent impact toughness at ultralow temperature of 196 DEG C below zero and has potential for replacing 9% Ni steel; and the cost of the experiment steel is far lower than that of the 9% Ni steel.