The invention discloses low-temperature ductility 1.5Ni steel and a manufacturing method thereof, wherein the low-temperature ductility 1.5Ni steel comprises the chemical components according to percentages by weight of 0.02-0.10 percent of C, 0.22-0.30 percent of Si, 1.00-1.50 percent of Mn, less than or equal to 0.08 percent of V, 1.20-1.60 percent of Ni, less than or equal to 0.005 percent of S, less than or equal to 0.010 percent of P, less than or equal to 0.03 percent of Nb, less than or equal to 0.04 percent of Ti, less than or equal to 0.04 percent of Al, 0.002-0.005 percent of N and the rest of Fe and unavoidable impurities. The manufacturing method comprises the following steps of smelting and casting into a casting blank, heating the casting blank, controlled rolling and heat treatment. In the invention, after the micro alloy steel finishes the controlled rolling, a high-strength low-temperature pressure vessel steel plate which has yield strength of more than 400MPa, tensile strength of more than 500MPa and satisfies the low-temperature impact ductility requirement of 100 DEG C below is produced through adopting a thermal refining method. The invention is suitable for manufacturing vessels, such as a low-temperature pressure vessel, a liquefied natural gas storage tank, a liquefied petroleum gas storage tank, a petrochemical storage tank, and the like.