The invention discloses a medical image segmentation model compression method, and belongs to the field of medical image processing. The method comprises the following steps: aiming at a medical image segmentation basic model, constructing a search space according to the number of convolution kernels used at each position in the model, aiming at a coding-decoding structure of a segmentation network, searching a sub-network with small calculation amount and high segmentation precision in the search space by using a symmetric neural network, and carrying out segmentation on the sub-network, wherein the coding and decoding structures are symmetrical, and weight sharing policies are used to mitigate computational costs and training resources when traversing the entire search space; finally, by using a knowledge distillation method in the network training process, the basic model serving as a teacher mode, the compressed sub-network serving as a student model, and completing the knowledge transfer between the basic model and the student model. Through neural network search and knowledge distillation, the calculation cost of network construction is greatly reduced on the premise of ensuring the segmentation effect of the medical image segmentation model, and the method can be applied to various medical image segmentation models.