The invention discloses a logistics clamping holding machine. The machine structurally comprises a machine frame, a transverse guide rail, a driving box, a longitudinal guide rail and a clamping holding structure, wherein the transverse guide rail is horizontally installed at the upper end of the machine frame, the driving box is installed between the transverse guide rail, the longitudinal guiderail is vertically embedded into the inner sides of the driving box, and the clamping holding structure is vertically installed at the lower end of the longitudinal guide rail; and the clamping holding structure comprises a sliding rail, a supporting frame, an air cylinder, a sliding block and clamping holding plates, wherein the sliding rail is horizontally installed at the lower end of the supporting frame, the sliding block sleeves the outer side of the sliding rail, the air cylinder is installed between the clamping holding plates, and the clamping holding plates are vertically and fixedlyarranged at the lower end of the sliding block. According to the logistics clamping holding machine, the clamping holding plates are arranged at the lower end of the sliding block, so that right-angle limitation is better formed for the outer side of a carton, the situation that the carton is deviated due to uneven stress is prevented, and the integrity of the outer side smooth surface of the carton is guaranteed; and meanwhile, a suction cup structure is arranged on the inner side of an exhaust structure so that the outer side of the carton can be sucked, and the carton can be further clamped and held more tightly, thereby preventing deviation.