The invention discloses a centralized control unmanned aerial vehicle resisting system based on sound wave attacking. The centralized control unmanned aerial vehicle resisting system comprises a master control and display device, an early warning equipment group, a positioning track equipment group and a sound wave attacking equipment group; early warning equipment transmits detected early warning zone target position information to the master control and display device in real time, movement locus display is carried out through the master control and display device, when a target enters a track zone, positioning track equipment and sound wave attacking equipment are selected for the target, early warning detection on the target is stopped, meanwhile, the position information of the target is obtained through the positioning track equipment, and real-time aiming of the sound wave attacking equipment on the target is achieved; and when it is detected that the target enters an attacking zone, the sound wave attacking equipment is controlled to issue sound wave attacking, crashing caused by resonance of the target is avoided, whether the target is crashed or not is detected through a detector of the positioning track equipment, and the sound wave attacking equipment is controlled to stop attacking if the target is crashed. According to the embodiment, intelligent judgment and physical crashing can be carried out on multiple unmanned aerial vehicle targets at the same time.