31results about How to "Increase driving pressure" patented technology

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

This relates to an improved delivery system for accurately loading and controlling the delivery of flowable material to a patient. Particularly, the system may be used in the injection of hard tissue implant materials such as PMMA under pressures up to about 4000 psi. The system includes an applicator with a first column having an implant material introduction section adapted to provide for effective loading of the implant material and a second column housing a piston. The introduction section has a larger size than that of a vessel section or bore in which the requisite pressure seal between the piston and bore wall is formed. The first column may include an introduction section flared open to an included larger funnel-like opening or a separate funnel may be used that interfaces with the introduction section to facilitate the introduction of implant material. Handles on the first and second columns to be turned relative to each other to advance the columns toward each other may be provided for manual actuation of the applicator to drive implant material through a cannula and deliver implant material to a desired site.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

A pipe conduit vehicle having a substantially cylindrical housing and with at least one ring-shaped sealing element disposed between the outer side of the housing and the inner wall of the pipe conduit can be moved in the pipe conduit via the transport fluid flow. The pipe conduit vehicle thereby comprises at least one inlet opening and at least one outlet opening which form a bypass through the inner portion of the housing to reduce the pressure differential before and after the pipe conduit vehicle, wherein the at least one inlet opening is disposed on the outer surface of the cylindrical housing.

A gas delivery apparatus for supplying an oxygen/air mix to a patient is discussed. Besides the conventional ability to adjust oxygen/air ratio independently via changes in the primary and/or secondary oxygen flow tube's flow rate adjustments, a flow meter is provided in the primary oxygen flow tube to give an accurate reading of the total flow of the oxygen/air mix exiting the venturi chamber of the apparatus.

A naturally aspirated, fully aerated radiant burner and optional heat exchanger arrangement where the radiant burner has a generally enclosed cavity defined, at least in part, by fuel gas impermeable surroundings and a lower surface of fuel gas permeable burner element, wherein cavity preferably has two opening exposed to an oxidizer source. Sealingly coupled to openings are mix tubes, each having respective first ends and second ends, wherein first ends occupy openings and second ends extend into and are exposed to cavity. Fuel gas injectors, which during use are in fluid communication with fuel gas, are positioned to introduce fuel gas into mix tubes and entrain only slightly more air than needed for stoichiometric combustion. Pre-combustion gasses migrate to upper surface where stable stoichiometric combustion occurs, resulting in low CO and NOx emissions, increased wind resistance and elevated combustion gas temperatures Connecting the heat exchanger directly to the burner further increases its wind resistance and prevents dilution of the combustion gases by wind or free convection.

A turbine blade for a turbine engine having a cooling system in the turbine blade formed from at least one elongated tip cooling chamber forming a portion of the cooling system and at least partially defined by the tip wall proximate to the first end. An inner surface of the tip wall may include a plurality of curved bumper protrusions extending from the inner surface radially inward toward the root. The cooling system may include a plurality of ribs generally aligned with the trailing edge, and the curved bumper protrusions may be offset in a chordwise direction relative to the ribs. A throat section may extend between a first forwardmost curved bumper protrusion and a second immediately adjacent downstream curved bumper protrusion and may be offset radially outward from an inner tip surface, thereby creating a first recessed tip slot with a reduced tip wall thickness.

A piezoelectric microvalve employs a valve element formed of hermetically sealed and opposed plates flexed together by a cross axis piezoelectric element. Large flow modulation with small piezoelectric actuator displacement is obtained by perimeter augmentation of the valve seat which dramatically increases the change in valve flow area for small deflections.

The invention provides a stepped aerogenesis dry powder extinguishing device. The stepped aerogenesis dry powder extinguishing device comprises a tank body, a piston assembly and a stepped aerogenesis device; dry powder extinguishing agents are stored in the tank body; the tank body is provided with a first end and a second end; the first end of the tank body is provided with a pipeline connector for being connected with a flow collection pipeline, the pipeline connector is internally provided with a damp-proof diaphragm, and the second end of the tank body is provided with a lower end cover; the piston assembly is slidably arranged on the inner side of the tank body, and the middle of the piston assembly is provided with a pressure diaphragm; and the stepped aerogenesis device is arranged in a space which is formed between the lower end cover and the piston assembly. According to the stepped aerogenesis dry powder extinguishing device, the initial pressure of the extinguishing device is not too high during extinguishing, moreover, the pressure lasing time is long, and the extinguishing device is very suitable for an automatic extinguishing system with a long flow collection pipeline.

This application relates to a method of sealing machine components using electroactive materials that can be energized through a separate electric circuit or electric field in order to eliminate most friction and deformation losses during a sealing process.

An adjustable nail clipper supports a foot of a user to clip toe nails of the user. The adjustable nail clipper comprises a support leg assembly, a hollow shaft, a handle, a clipper head with cutting blades, and a foot rest. The hollow shaft extends from an upper end of the support leg assembly, and the handle is attached to the hollow shaft. The clipper head is attached proximal to a bottom end of the hollow shaft, and the cutting blades of the clipper head are actuated via a clipping lever attached to the hollow shaft. The foot rest is pivotally connected to the hollow shaft, and positioned frontally to the clipper head. The foot rest is configured to receive and support the foot of the user seated on a chair, and to allow the user to clip each toe nail after aligning each toe nail between the cutting blades.

The present invention provides materials and methods for using electrical stimulation to treat a mammal having a proteinopathy (e.g., neurodegenerative diseases) or at risk of developing a proteinopathy are provided. For example, the present invention provides materials and methods for modulating glymphatic clearance (e.g., enhancing glymphatic clearance) of pathogenic proteins.

A tip clearance control (TCC) system 100 is provided to control the gap 176 between the tips of turbine blades 172 of a gas turbine engine 10 and the casing 174 within which they rotate. The inlet 120 to the TCC system is provided in a bifurcation panel 110 that extends across a bypass duct 22 of the gas turbine engine 10. The inlet is provided on a first major surface 112 of the bifurcation panel 110 that is defined such that the direction (R) that points through the bifurcation panel from the first major surface 112 to a second major surface 114 corresponds to the fan rotation direction. This provides a particularly effective and/or efficient TCC system 100.