The invention discloses an ampoule bottle neck automatic opening system. The system comprises a rack, an intermittent rotary disc, an ampoule bottle input device, an ampoule bottle label information detection device, an alcohol disinfection device, a grinding wheel assembly, a bottle neck breaking device, an ampoule bottle output device, a vertical shaft, a motor and a bottle neck collecting box.The ampoule bottle input device, the alcohol disinfection device, the grinding wheel assembly, the bottle neck breaking device and the ampoule bottle output device are distributed at the periphery ofthe intermittent rotary disc; and when the ampoule bottle rotates to a breaking station, the bottle neck breaking device breaks the bottle neck of the ampoule bottle, and the broken bottle neck fallsinto the bottle neck collecting box through a bottle neck through hole. By the adoption of the structure, full-automatic operation of automatic feeding, disinfection, scratch cutting, breaking and automatic output of the ampoule bottle is achieved, a batch of ampoule bottles can be conveniently and automatically opened, the workload of medical staff is greatly reduced, and the system is convenientto move and easy and convenient to operate and use. The system has the characteristics of high automation degree, streamlined operation and small and compact structure.