The invention provides an adjustable vehicle spare tire frame which comprises a main body, two fixing bases, two vertical boards, a main shaft, a pressing board, a locking nut, two tire pressing boards, two first supports, two second supports, two first adjusting nuts, two second adjusting nuts and two adjusting screw rods, wherein the main body is disc-shaped, the fixing bases and the vertical boards are respectively and fixedly installed at the left side and the right side of the main body, the main shaft is installed in the center of the main body, the pressing board and the locking nut are concentrically fixed, the first supports and the second supports are respectively and fixedly installed at the upper part and the lower part of the main body, through holes are formed in the middle positions of the first supports and the second supports, the adjusting screw rods are respectively arranged on the through holes in the first supports and the second supports, and the tire pressing boards are respectively and fixedly installed on the adjusting screw rods. The adjustable vehicle spare tire frame can play the role of dismantling a spare tire fast and conveniently, and effectively guarding against theft and loss.