The invention relates to the technical field of intelligent substation electrical secondary design, in particular to an intelligent substation integrated information platform and a using method thereof. The system comprises a first safety area and a second safety area, an isolation module is arranged on a communication link between the first safety area and the second safety area, and a central control system, a video monitoring subsystem, a three-dimensional animation model subsystem and a black box system are arranged in the first safety area. A fire-fighting subsystem, an environment monitoring subsystem, an inspection subsystem, an equipment state acquisition subsystem and a security subsystem are arranged in the second safety area, the isolation module comprises a forward isolation device and a reverse isolation device, and the data transmission direction of the forward isolation device is from the first safety area to the second safety area; the data transmission direction of the reverse isolation device is from the second safety area to the first safety area; according to the invention, the problems of information islands, limited monitoring capability and the like in the prior art can be effectively solved.