5 results about "Diabetes types" patented technology

The invention relates to the technical field of medical time sequence data disease typing, and discloses a typing diagnosis system for diabetes mellitus. According to the system, time sequence data of a patient is generated through data preprocessing, segmentation is carried out through multi-scale sliding windows, statistical characteristics and trend slopes of physiological indexes are synchronously calculated in all the windows, and a mode track of healthy evolution of an individual is constructed. And dividing a diabetes subtype prototype by mapping the trajectory to a high-dimensional space. For a new data point, calculating a multi-dimensional distance and a migration probability from the new data point to each prototype, and generating a preliminary subtype membership degree vector; and feeding the vector back to a trajectory construction process, dynamically adjusting window parameters and calculating weights in an iteration mode, and outputting a stable personal health trajectory and an updated membership after optimization. And finally, the structured subtype diagnosis with confidence is generated through fusion. The system realizes dynamic, accurate and individualized typing of diabetes subtypes.

The application relates to the technical field of medical time series data disease typing, and discloses a diabetes typing and diagnosing system. The system comprises the following steps: generating patient time series data through data preprocessing, and cutting through a multi-scale sliding window, synchronously calculating statistical features and trend slopes of physiological indexes in each window, and constructing a mode trajectory of individual health evolution. The trajectory is mapped to a high-dimensional space to divide diabetes subtypes. For a new data point, multi-dimensional distances and migration probabilities to each prototype are calculated to generate a preliminary subtype membership vector. The vector is fed back to the trajectory construction process to dynamically adjust window parameters and calculation weights in an iterative manner, and after optimization, a stable personal health trajectory and an updated membership are output. Finally, a structured subtype diagnosis with a confidence level is generated. The system realizes dynamic, accurate and individualized typing of diabetes subtypes.

The invention discloses a GCKR gene mutation diabetes diagnosis kit and application thereof. The method comprises the following steps: determining two new gene mutation sites causing the presentation of the phenotype of type 2 diabetes mellitus: GCKR gene c.718Cgt; t, c, 1551Ggt; t mutation. According to a Chinese hereditary endocrine metabolic disease queue and reported GCKR mutation case information, GCKR gene mutation diabetes diagnosis sites are further expanded, phenotypic characteristics of novel diabetes caused by GCKR gene mutation are further extracted, a diagnosis scoring model, namely GCKR scores, for diagnosing the novel diabetes caused by GCKR gene mutation is constructed, and the GCKR scores are used for diagnosing the novel diabetes caused by GCKR gene mutation. And performing subject working curve verification to obtain an effective GCKR score diagnosis model. According to the method, a precise diabetes typing diagnosis system is further constructed, and after variation information is obtained, the patients are scored and typed again in combination with clinical phenotypes of the patients, so that precise diagnosis of diabetes is carried out. According to accurate typing of diabetes, patients are treated, complications are monitored and prevented, and grading guidance is performed on prenatal and postnatal care.

The invention discloses a diabetes typing marker based on a D2D3-TROY signal axis, a new medical application of valprophylline and a kit for diagnosing a specific diabetes subtype.

The invention provides application of a compound shown in a formula (I) in preparation of a medicine for improving male reproductive capacity. According to the application, a nano micro-plastic and plasticizer induced Kunming mouse environment pollution type oligospermia and asthenospermia model, a streptozotocin induced Kunming mouse diabetes type oligospermia and asthenospermia model and a sodium valproate induced Kunming mouse anti-epileptic drug type oligospermia and asthenospermia model are respectively constructed; the improvement effect of the compound shown in the formula (I) on male reproductive capacity damage is verified through sperm counting analysis, sperm motility analysis, inflammation and antioxidant gene mRNA expression level analysis, testis tissue pathological damage analysis and the like, and experimental results show that the compound shown in the formula (I) increases the sperm number of mice suffering from oligospermia and asthenospermia, and has a good application prospect. According to the application, the sperm motility of mice with oligospermia and asthenozoospermia is improved, the tissue pathological damage of the testis is improved, the expression of inflammatory factors is inhibited, the expression of antioxidant genes is increased, and the application has great potential in the aspect of treating oligospermia and asthenozoospermia.