2 results about "Hb vaccine" patented technology

This invention discloses a biological agent for enhancing the immune response to hepatitis B vaccine using *Bifidobacterium adolescentis*, comprising: a preparation of *Bifidobacterium adolescentis* and a hepatitis B vaccine. The *Bifidobacterium adolescentis* preparation is a live *Bifidobacterium adolescentis* capsule. The live *Bifidobacterium adolescentis* capsule uses *Bifidobacterium adolescentis* live capsules from Lizhu Chang Le. The hepatitis B vaccine is a recombinant yeast hepatitis B vaccine. The recombinant yeast hepatitis B vaccine uses a recombinant hepatitis B vaccine from *Saccharomyces cerevisiae*. In high-responder populations receiving hepatitis B vaccine booster vaccination, the intestinal flora is rich in *Bifidobacterium adolescentis* 8 weeks post-vaccination. KEGG function analysis indicates that the intestinal flora function of high-responder populations is stronger than that of low / non-responder populations to hepatitis B vaccine. Bifidobacterium is positively correlated with various metabolic functions. Oral administration of *Bifidobacterium adolescentis* can enhance the immune response to hepatitis B vaccine.

The invention relates to the technical field of hepatitis B vaccine production, and discloses a hepatitis B vaccine production whole process quality monitoring and early warning system, which comprises the following modules and components: a system initialization and basic construction module, a production whole link quality monitoring module, and a system dynamic optimization and upgrade module. The system initialization and basic construction module comprises a supplier qualification auditing terminal, a sensor cluster, RFID read-write equipment, an early warning terminal, a raw material quality standard database, a supplier basic archive library, a supplier rating subsystem, an LSTM process prediction model training platform, a parameter threshold setting terminal and an early warning level setting unit; the production whole-link quality monitoring module comprises a raw material purchase admission control sub-module, an engineering bacterium fermentation real-time monitoring sub-module, a purification and inactivation precise control sub-module and a stock solution and semi-finished product quality comprehensive evaluation and early warning sub-module; the objective of the invention is to solve the problem that the instantaneity and comprehensiveness are seriously insufficient.