The invention discloses a single-
cell multi-
omics translation method based on comparative learning, and relates to the technical field of
cell sequencing, and the method comprises the following steps: judging whether a first mode and a second mode are paired
modes or not; if yes, generating a
feature matrix; if not, obtaining a
feature matrix through an auxiliary network
encoder, a
core network encoder and a clustering module in sequence; the
feature matrix sequentially passes through data enhancement and an auxiliary network
encoder to obtain a first
hidden layer feature; judging whether the first
hidden layer feature contains a space coordinate or not; if not, sequentially performing data enhancement, a
core network encoder and a translator on the first
hidden layer feature to obtain a second hidden layer feature; if yes,
feature coding is carried out on the first hidden layer feature, and then a second hidden layer feature is obtained; and translating the second hidden layer feature through the
core network decoder and the auxiliary network decoder in sequence to obtain a first mode and a second mode. According to the method, the translation model can learn real
cell type characterization, so that counterfeit
elimination, true storage and interpolation supplement are realized.