The invention relates to a missile comprehensive test simulation system, which can carry out pre-installation test, post-installation test and flight simulation for semi-active laser air-to-ground missiles and missile-borne equipment, so as to check the coordination and correctness of the work of the whole missile and missile systems. It is characterized in that it includes two parts: a computer part and an electromechanical part, and the computer part includes four parts: a test machine, a simulator, a board card and a power supply unit; the electromechanical part includes a missile supporting mechanism, a target moving mechanism, a turntable and a laser target simulator and other auxiliary equipment. The system has the function of automatic batch test, the test items are optional, the format of the test data is unified and standardized, and the curve can be dynamically displayed along with the test process. The system is an independent box structure, and the missile support mechanism and target movement mechanism can be disassembled, which is convenient for transportation and field operation.