The invention relates to a goaf grouting treatment method for secondary mining of an old goaf of an extra-thick coal seam. The method comprises the following steps: step 1, determining a plane boundary of a re-mining area; 2, calculating and determining a re-mining treatment vertical boundary; 3, determining the layout mode of ground directional drilling and underground drainage drilling, the probing layer position, the horizontal distance, the construction sequence and the drilling structure requirement; 4, parameters such as grouting materials, pressure, ending standards, grouting sequences and cooperation of grouting and drilling under different working conditions are determined; and 5, checking and reinforcing the grouting filling effect. The method effectively solves the problem of safe and efficient mining of multiple disasters such as water disasters, fire areas, harmful gases and broken roofs confronted by re-mining of residual coal in the extra-thick coal seam in a non-standard mining mode in the prior art, good effects of multi-disaster-source disaster control, space filling and coal rock consolidation in a re-mining area are achieved, and favorable conditions for safe mining are created for re-mining of residual coal in the extra-thick coal seam.