The invention relates to a high-reliability and low-false alarm rate highway automobile anti-collision system and method. The highway automobile anti-collision system comprises a central processing unit, radar, a steering wheel angle sensor, a vehicle speed sensor, a steering lamp sensor, a camera, a location speed measurement sensor and an output unit, wherein the radar communicates with the central processing unit. The technical problem that the false alarm rate of a traditional radar automobile intelligent anti-collision system is high is solved by the highway automobile anti-collision system. According to the highway automobile anti-collision system, by utilizing the multi-sensor fusion technique, the advantages of all the sensors are fully exploited; the integrated information of people, vehicles and roads is provided, and therefore, false alarms caused by traffic signs, temporary passage vehicles, roadside buildings, curves, overtaking and platform bridges are reduced, unreal obstacles are eliminated, and the false alarm rate under the complicated environment is reduced.