The invention relates to a nano samarium oxide-modified monomer casting (MC) nylon sliding block and a production process thereof. The nano samarium oxide modified MC nylon sliding block comprises the following materials: 100 parts by weight of master batch hexanolactam, 0.5-1.0 part by weight of nano samarium oxide, 0.12-0.2 part by weight of accelerator sodium hydroxide, 0.3-0.7 liter of curingagent TDI (toluene diisocynate), 2-3 parts by weight of solid lubricant molybdenum disulfide, 0.5-0.8 part by weight of graphite, and 0.3-0.5 part by weight of boron nitride. The production process comprises the specific production steps of: heating up a die, feeding the materials, solidifying for molding, processing internal stress, and machining. The product disclosed by the invention can transfer the born external stress well, as well as can bend a matrix to consume a lot of impact energy, so that an effect for simultaneously increasing the toughness and strength of the product is obtained. According to the production process of the product, disclosed by the invention, a centrifugal casting technology is adopted, so that internal air holes of the product are eliminated, and product quality problems of steel casting sliding blocks caused by defects such as internal air holes, inclusion and the like are solved.