The invention provides an acellular
dermal matrix guided tissue regeneration membrane material as well as a preparation method and application thereof, and relates to the technical field of medical
biological materials. The preparation method provided by the invention comprises the following steps: pretreating, removing an epidermal layer, preparing a loose surface, stabilizing, performing the accellular treatment, washing, and sterilizing. A membrane material prepared by the method provided by the invention adopts
fish skin as a
raw material and has a three-dimensional space framework structure, and comprises a compact surface formed by a biological substrate membrane and a collagen loose surface formed by a dermal
scaffold. By adopting the membrane material provided by the invention, therisk of the existing tissue restoration material in carrying and propagating the human-animal viruses can be avoided, the
cell components can be completely removed, the
immunogenicity is low, the clearance of the collagen fibers is increased, a corium layer structure is reserved, the
tissue compatibility is good, the mechanical
shielding effect is good, and the generation of new bones can be facilitated; and when used for restoring and treating the bone deficiency of an oral implantation operation, the material is digestible, and the second operation and the injury of the membrane material topatients can be effectively avoided.