The invention discloses a rack-matching lifting weeding pesticide mixing device for farming. The device comprises a base, an outer frame, sliding columns, a mixing box, stirring blades and spoilers, wherein the mixing box is arranged between lifting sliding blocks located on the two sides, gears are in interference fit with the centers of stirring shafts, the stirring blades are arranged on the two sides of each gear and installed on the stirring shafts, a screw is rotatably installed between the two sets of stirring shafts above and below through bearings, translational sliding blocks are installed on the left and right threads of the screw through the threads respectively, and the spoilers are installed on the upper and lower sides of the translational sliding blocks in an embedded moderespectively. By driving the mixing box to move upwards, vertical movement of the mixing box is achieved, thus the flow rate of pesticide in the mixing box is improved, and the pesticide is mixed moreevenly; the screw rotates and moves in the positive and negative directions to drive the translational sliding blocks on the two sides to move towards the middle or the two sides simultaneously, so that the spoilers move towards the middle or the two sides simultaneously, the spoilers play a part in turbulence, and thus a better mixing effect is achieved.