The invention discloses a split type inverted wedge type power chuck for a machine, which mainly comprises a chuck body, a sliding seat, a T-shaped key, a clamping jaw, a dustproof cover, a sliding shaft, a location key, a regulating pad and a pull rod, wherein an integral semi-closed structure of a guide groove is changed into an open surface, thus groove width precision and smooth finish of a guide surface are improved, and movement precision and service life of the chuck are improved; and by adopting an inverted cone chuck, the split type inverted wedge type power chuck has replaceability. By adopting round corner transition, the diameter range of clamping a workpiece is increased. A packing and a guide block of the chuck are separately manufactured, and then assembled into a whole, thus the split type inverted wedge type power chuck has the advantages of compact structure, convenience for maintenance, large clamping range, convenience for regulation, adjustable clamping force, higher automatic centering precision and the like.