The invention provides an image noise reduction method and device, electronic equipment and a storage medium. The method comprises the following steps: acquiring a plurality of frames of original images, synthesizing according to the plurality of frames of original images to obtain a high-dynamic-range image, determining a matched noise reduction model according to ambient brightness, and performing noise reduction on the high-dynamic-range image by adopting the noise reduction model to obtain a target noise reduction image. According to the method, the ambient brightness of a plurality of frames of original images is collected, after a matched noise reduction model is determined, noise reduction processing is carried out on a high-dynamic-range image, and more image details are reserved while the image purity is ensured. In addition, noise reduction processing is carried out after multiple frames of original images are synthesized; therefore, both the bright light area and the dark light area in the synthesized high-dynamic-range image can be denoised, the noise reduction effectiveness is improved, image details are reserved while the image noise of the target noise-reduced image obtained through noise reduction is reduced, and an imaging effect with better definition is obtained.