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The application discloses a universal joint ball pair locking mechanism and medical equipment, and relates to the field of medical equipment. The universal joint ball pair locking mechanism comprises a ball joint and a locking assembly. The ball joint comprises an inner ball head and an outer ball body which are hingedly connected with each other. The locking assembly comprises a first engaging member, a second engaging member and an unlocking driving member. The application realizes rigid locking through the engagement of the first engaging member and the second engaging member. The locking design is not affected by factors such as changes in the friction coefficient and wear, and can stably maintain the relative angle of the inner ball head and the outer ball body, thereby avoiding adverse loosening caused by friction failure and improving the stability of the locking strength. The locking assembly has two states of locking and unlocking. When unlocked, the inner ball head and the outer ball body can be universally adjusted, thereby meeting the requirement of flexible equipment to reach a target position and angle. When locked, stable support is provided through rigid engagement, and the use requirements of flexible adjustment and reliable locking are considered, so that the application is well applicable to application occasions of the stability of equipment operation.