The invention relates to the technical fields of active noise reduction and communication, in particular to a cloud service-based active noise reduction earphone design system and method. According tothe cloud service-based active noise reduction earphone design system and method, local active noise reduction design systems and a cloud server are included, wherein each local active noise reduction design system comprises an earphone wearing device, a data acquisition device, a to-be-designed noise reduction earphone and a monitoring device. Compared with an existing active noise reduction on-line design system, the system and method have the advantages that parameters of the noise reduction system can be designed on line according to the vocal cavity characteristic of each to-be-designedactive noise reduction earphone, all the active noise reduction earphones designed by adopting the system can achieve an excellent noise reduction effect, and it can be guaranteed that the noise reduction performances of the designed active noise reduction earphones have the good consistency; and meanwhile, by adopting the cloud server to design the noise reduction parameters, the computing speedis increased, the computing performance is improved, the burden of a user side is reduced, the requirement of serving design of multiple noise reduction systems simultaneously is met.