45results about How to "Severe damage" patented technology

The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.

The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.

The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.

A protective cover assembly used to cover and protect windows, doors or other wall openings for homes, office buildings, hotels, and other walled structures from the destructive forces of a high windstorm, such as a hurricane. The current form of the preferred embodiment consists of a high strength fabric covering an opening, such as a window and being supported by brackets, a rod and a bar. Once installed, the high strength fabric is stretched over the opening, through the use of a gears and ratchet assembly. The high strength fabric once stretched will provide protection from high winds and wind borne debris common in storms such as hurricanes. The protective cover assembly also prevents unlawful entries or break-ins of buildings. The high strength fabric is securely supported to the rod and steel bar that are firmly attached to the wall structure near the wall opening.

This invention provides a method of treating a subject afflicted with active lupus arthritis comprising periodically administering to the subject an amount of laquinimod or pharmaceutically acceptable salt thereof effective to treat the subject. This invention also provides laquinimod or pharmaceutically acceptable salt thereof for use in treating a subject afflicted with active lupus arthritis. This invention further provides a pharmaceutical composition comprising an amount of laquinimod or pharmaceutically acceptable salt thereof for use in treating a subject afflicted with lupus arthritis.

Normal tissue complications limit curative broadbeam radiotherapy to tumors including lung cancer. Radiation retinitis causing blindness limits quality of life and long term survival for patients with ocular melanoma. This invention pertains to alternative, normal tissue sparing 100 to 1,000 Gy microbeam radiations with least normal tissue complications and concomitant radio-immunotherapy by innate immune response of epidermis and dermis to low dose radiation with 50 kV X-rays. Total body skin radiation with former airport passenger screening machines with 50 kV X-ray is disclosed. Microbeams are generated without contaminating scatter and neutron radiations from collinear gamma ray and electron beam produced by inverse Compton interaction with high energy laser and electron beam and from proton and carbon ion beams in tissue equivalent cylindrical collimators. Extracorporeal immunotherapy and chemotherapy and apheresis of mutated subcellular particles released into circulation in response to cancer-therapies are by clinical continuous flow ultracentrifugation combined chromatography.

A multi-pole synchronous pulmonary artery radiofrequency ablation catheter, wherein an adjustment apparatus is arranged on a control handle; a catheter body is hollow, and a cavity is arranged therein; a lead wire, a temperature sensing wire and a pull wire are arranged in the cavity; one end of the catheter body is flexible, and the flexible end is connected to an annular ring; the other end of the catheter body is connected to the control handle; one end of the pull wire is connected to the flexible end, and the other end of the pull wire is connected to the adjustment apparatus on the control handle, the tension of the pull wire is adjusted through the adjustment apparatus to achieve radian control of the flexible end; a shape memory wire is arranged in the annular ring, one end of the shape memory wire extends to the end of the annular ring and the other end of the shape memory wire passes through the root of the annular ring and is fixed on the flexible end of the catheter body; the annular ring is provided with an electrode group with each electrode connected to the lead wire and temperature sensing wire; the lead wire and temperature sensing wire go through the catheter body and are electrically connected to the control handle. The device uses cold saline perfusion method to protect the vascular intima and possesses advantages of simple operation, short operation time and controllable precise ablation. The device can be used to treat pulmonary hypertension with pulmonary denervation.

Derailment control system for railway vehicles that, in addition to detecting and issuing a warning of said derailment, provides control over the brake of the derailed vehicle or vehicles and provides additional emergency braking and / or a warning to the driver's cab, said system having a main unit (1) to which are joined: an inertia sensor or detector (8) designed to detect derailments, an indicator (9) or device responsible for indicating that the derailment control system has been triggered and for keeping the system activated, a stopcock (10) that deactivates the derailment control, and a bottom connection point (11) for testing that makes it possible to simulate a triggering of the system via a threaded eyebolt, facilitating verification of proper operation both during bench testing and when the system is installed on the vehicle (7), and a device (39) situated at the exhaust outlet through which the automatic brake pipe (ABP)(5) is vented when said derailment is detected.

A shock absorbing trailer hitch attachment for vehicle protection is presented. A shock absorbing attachment is inserted into the trailer hitch receiver tube of any vehicle with an existing trailer hitch. The trailer hitch attachment contains shock absorbing capabilities and is designed to compress in order to reduce impact to the vehicle. Specifically, this attachment minimizes the amount of shock forces on a vehicle's bumper, via impact, between other vehicles, structures, and objects. The attachment does not require alteration of existing trailer hitch receivers and will add purpose to the routinely underutilized trailer hitch.

A connector arrangement for a fluid system includes a fuel injector that defines a first fluid passage having a connector, a pipe that is engageable with the connector of the first fluid passage, preferably to form a high pressure seal, and a nut arranged to connect the pipe to the connector of the first fluid passage. A chamber is defined between the nut and the fuel injector, such chamber serving to collect leaked fluid from the first fluid passage. The fuel injector is provided with a second fluid passage having a first end in communication with the chamber and a second end in communication with a low pressure drain such that leaked fuel is provided with a drain path.

A damper actuator motor device includes a fan brake device which is secured to a motor rotor shaft and is configured to reduce motor rotation speed in a preferential direction. Preferably, the fan brake device has an asymmetric configuration, and is adapted to gather air radially in an enclosed cavity and discharge it axially in one direction. The fan device preferably is adapted to project a size that takes up more than half of the space of the cavity. When the motor is back driven, the fan brake device causes differentially pressure and air resistance in a confined area, producing a drag and braking force that increases with motor speed. The invention can be applied to motor actuators used to control air dampers and other valves in gas or fluid delivery systems. The invention can also be used to reduce water hammer in water delivery systems.

A multi-pole synchronous pulmonary artery radiofrequency ablation catheter, wherein an adjustment apparatus is arranged on a control handle; a catheter body is hollow, and a cavity is arranged therein; a lead wire, a temperature sensing wire and a pull wire are arranged in the cavity; one end of the catheter body is flexible, and the flexible end is connected to an annular ring; the other end of the catheter body is connected to the control handle; one end of the pull wire is connected to the flexible end, and the other end of the pull wire is connected to the adjustment apparatus on the control handle, the tension of the pull wire is adjusted through the adjustment apparatus to achieve radian control of the flexible end; a shape memory wire is arranged in the annular ring, one end of the shape memory wire extends to the end of the annular ring and the other end of the shape memory wire passes through the root of the annular ring and is fixed on the flexible end of the catheter body; the annular ring is provided with an electrode group with each electrode connected to the lead wire and temperature sensing wire; the lead wire and temperature sensing wire go through the catheter body and are electrically connected to the control handle. The device uses cold saline perfusion method to protect the vascular intima and possesses advantages of simple operation, short operation time and controllable precise ablation. The device can be used to treat pulmonary hypertension with pulmonary denervation.

First, on a semiconductor region of a first conductivity type, a trapping film is formed which stores information by accumulating charges. Then, the trapping film is formed with a plurality of openings, and impurity ions of a second conductivity type are implanted into the semiconductor region from the formed openings, thereby forming a plurality of diffused layers of the second conductivity type in portions of the semiconductor region located below the openings, respectively. An insulating film is formed to cover edges of the trapping film located toward the openings, and then the semiconductor region is subjected to a thermal process in an atmosphere containing oxygen to oxidize upper portions of the diffused layers. Thereby, insulating oxide films are formed in the upper portions of the diffused layers, respectively. Subsequently, a conductive film is formed over the trapping film including the edges thereof to form an electrode.

An ice dispense system for an ice dispenser is characterized by a chute having an ice receiving upper end in communication with an ice bin outlet passage and an ice dispensing lower end. Beginning with the chute filled with ice and its lower end closed, to dispense a selected quantity of ice, the chute lower end is opened for one of a plurality of different time periods, where each individual time period of the plurality is of a duration to dispense from the chute an associated predetermined quantity of ice. In response to dispensing ice from the chute, an agitator in the bin is operated for one of a plurality of different time periods, where each individual time period of the plurality is of a duration to move through the bin outlet passage and into the upper end of the chute an amount of ice substantially equal to that dispensed. The ice dispensing system is provided with an improved user interface and user programmable features.

A multi-pole synchronous pulmonary artery radiofrequency ablation catheter may comprise a control handle, a catheter body and an annular ring. One end of the catheter body may be flexible, and the flexible end of the catheter body may be connected to the annular ring. The other end of the catheter body may be connected to the control handle. A shape memory wire may be arranged in the annular ring. One end of the shape memory wire may extend to an end of the annular ring and the other end of the shape memory wire may pass through a root of the annular ring and be fixed on the flexible end of the catheter body. The annular ring may be provided with an electrode group. The device possesses advantages of simple operation, short operation time and controllable precise ablation. The device can be used to treat pulmonary hypertension with pulmonary denervation.

The present disclosure relates to a fiber-reinforced copper-based brake pad for high-speed railway train, and preparation and friction braking performance thereof. The fiber-reinforced copper-based brake pad for high-speed railway train comprises 80-98.5 wt. % metal powder, 1-15 wt. % non-metal powder and 0.5-5 wt. % fiber component. In addition, some components are added in a specific proportion to achieve optimal performance. The copper-based powder metallurgy brake pad is obtained by powder mixing, cold-pressing and sintering with constant pressure. The friction braking performance of the obtained brake pad is tested according to a braking procedure consisting of three stages, i.e., the first stage with low-pressure and low-speed, the second stage with high-pressure high-speed and the continuous emergency braking third stage with high-pressure and high-speed. The brake pad has advantages including higher and more stable friction coefficient, higher fade and wear resistance and slighter damage to brake disc at high speeds.

A sealed lamp device may include a discharge lamp burner; a concave mirror opened to a front direction and reflecting radiation light of the discharge lamp burner to the opened side, an optical axis of the concave mirror being aligned with an optical axis of the discharge lamp burner; a hollow casing structure having an opening section in a front side, to which the concave mirror opened out; and a front plate closing the opening section of the hollow casing structure and emitting the radiation light. The hollow casing structure may be made wider than an opening width of the concave mirror, so as to increase a sealed volume occupied by the discharge lamp burner.

A tube plug insertable in one end of a heat exchange tube, the tube plug formed as an shaft having a distal part and an opposite proximal part which terminates in a proximal end with an threaded hole extending axially in the proximal end in the distal direction, and a plug removal tool having a proximal handle part and a distal stem part which has external threads that match threads in the threaded hole in the plug's shaft, the stem part being threadedly insertable into the threaded hole in the proximal end of the tube plug, whereby rotation of the stem will urge the tube plug to rotate relative to the heat exchange tube and break free from being lodged in the bore thereof.

The invention particularly provides a longhole pressure-bearing blasting method of hard coal rock and solves the problem that a conventional blasting roof control measure has a poor effect for a hard roof. The longhole pressure-bearing blasting method of the hard coal rock comprises following steps: roof caving hole construction is performed; then construction of charging holes is performed, the charging holes are 35 m long, angles of elevation are 9 degrees and 13 degrees, level angles are set as 15 degrees and 20 degrees, and large-diameter guiding holes are formed between the adjacent charging holes; the charging holes and the guiding holes are subjected to alternate spaced charging, a special hole sealing device provided with a liquid injection pipe and a drain pipe is adopted to seal orifices, and blasting is executed after liquid injection. With the adoption of the method, the utilization rate of explosive energy is high, only 70% of traditional explosive dosage is needed, the degree of damage to the coal surface is more severe, and the blasting is more efficient.

A road / rail vehicle has front and rear road wheels, an engine driving the rear road wheels, and an indicator of actual vehicle speed. Retractable front and rear rail wheels are mounted on the vehicle and movable from a raised road position for operation in a road mode to a lowered rail position where the rail wheels engage rails of a railroad track for operation in a rail mode. A suspension system is adjustable in the rail mode to vary a weight proportion of vehicle weight that is a tractive weight carried by the rear road wheels and a guidance weight carried by the rear rail wheels, and a suspension control is adjusts the suspension system to provide a selected weight proportion. A maximum allowable vehicle speed decreases as the tractive weight increases and a maximum speed indicator shows the maximum allowable vehicle speed for the selected weight proportion.

The invention relates to molecules for treatment and diagnosis of tumors and malignancies, comprising a tumor seeking biomolecule, which is coupled to an intercalating moiety, which is capable of complexing a metal, which metal is preferably a radioactive metal, to the use of these molecules and to therapeutic and diagnostic compositions containing them.

A torque converter check valve has a valve element movable between a closed position and an open position by applying hydraulic pressure to a portion of the valve element and by applying a resilient force by a resilient element acting on another portion of the valve element. A spacer element is provided to act on the valve element and limit movement of the valve element in the direction in which the resilient element is compressed to reduce wear on the resilient element during operation of the torque converter check valve.

A multi-pole synchronous pulmonary artery radiofrequency ablation catheter may comprise a control handle, a catheter body and an annular ring. One end of the catheter body may be flexible, and the flexible end of the catheter body may be connected to the annular ring. The other end of the catheter body may be connected to the control handle. A shape memory wire may be arranged in the annular ring. One end of the shape memory wire may extend to an end of the annular ring and the other end of the shape memory wire may pass through a root of the annular ring and be fixed on the flexible end of the catheter body. The annular ring may be provided with an electrode group. The device possesses advantages of simple operation, short operation time and controllable precise ablation. The device can be used to treat pulmonary hypertension with pulmonary denervation.

The present invention discloses a preparation method of plan-view TEM sample used in an integrated circuit analysis. The method comprises the steps of: providing a carrying slice, and fixing a chip containing a targeted structure sample and the carrying slice on a sample holder in a horizontal direction, and putting them in a process chamber of a FIB apparatus; cutting off a piece of chip structure containing a target structure sample by adopting a FIB; and welding the piece of chip structure on the flat and clean side of the carrying slice by using a nano-manipulator; after being taken out from the process chamber of the FIB apparatus, the carrying slice welded with the chip structure is adjusted to vertical direction, and is put in the process chamber of the FIB apparatus again; transferring and welding the chip structure on the TEM copper grid by using the nano-manipulator; and removing one layer or multiple layers above the preset target layer from the surface layer of the chip by using the FIB to obtain the desired plan-view TEM sample.

Mines are fabricated in the form of munitions, specifically including cartridges for firearms and several types of grenade, including both hand grenades and rocket-propelled grenades, the cartridges containing either very high energy explosives or very high temperature burning materials, that upon ignition will at least destroy the firearm in which fired or may exert lethal force against the user, while such mines in the form of grenades will explode immediately upon being activated rather than exhibit the expected time delay, both types of mines being supplied surreptitiously to an enemy force for its unknowing use, thereby to direct the lethal effect of such munitions against those enemy forces rather than the friendly forces as the enemy forces would have intended.

Methods and compositions for rejuvenating skeletal muscle stem cells are disclosed.

Electrical fault restricting system for an electrical equipment and / or electrical system has a monitoring unit placed at location of interest to sense or measure electrical fault occurred with the help of sensing or measuring device which is further connected to signal processing and controlling unit which receives data collected by the monitoring unit that provides output for fault identification, alarming and controlling actions to alarming. An indication unit and command for trip signal to circuit breaking device where processed data of data collecting and processing unit are stored at data history storage. A display unit for back reference monitoring unit provides images to image receiver. A processor and controlling unit further provides processed images to an additional data history storage and display unit for future analysis of conditions where plurality of signal processing and controlling unit is inter connected with additional remote central controlling and data handling unit.