45results about How to "Severe damage" patented technology

The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.

A multi-pole synchronous pulmonary artery radiofrequency ablation catheter, wherein an adjustment apparatus is arranged on a control handle; a catheter body is hollow, and a cavity is arranged therein; a lead wire, a temperature sensing wire and a pull wire are arranged in the cavity; one end of the catheter body is flexible, and the flexible end is connected to an annular ring; the other end of the catheter body is connected to the control handle; one end of the pull wire is connected to the flexible end, and the other end of the pull wire is connected to the adjustment apparatus on the control handle, the tension of the pull wire is adjusted through the adjustment apparatus to achieve radian control of the flexible end; a shape memory wire is arranged in the annular ring, one end of the shape memory wire extends to the end of the annular ring and the other end of the shape memory wire passes through the root of the annular ring and is fixed on the flexible end of the catheter body; the annular ring is provided with an electrode group with each electrode connected to the lead wire and temperature sensing wire; the lead wire and temperature sensing wire go through the catheter body and are electrically connected to the control handle. The device uses cold saline perfusion method to protect the vascular intima and possesses advantages of simple operation, short operation time and controllable precise ablation. The device can be used to treat pulmonary hypertension with pulmonary denervation.

A conveying device for objects, in particular for bottles, having a first conveyor, a second conveyor and an intermediate buffer communicating with said first and second conveyors via a first transfer site. In order to increase the flexibility of such a conveying device, the first and second conveyors are connected to the buffer separately from one another via a respective first transfer site. Also, a switchable intermediate conveyor is provided, which bypasses the buffer and which is in conveying connection with the first and second conveyors via a respective second transfer site.

A conveying device for objects, in particular for bottles, having a first conveyor, a second conveyor and an intermediate buffer communicating with said first and second conveyors via a first transfer site. In order to increase the flexibility of such a conveying device, the first and second conveyors are connected to the buffer separately from one another via a respective first transfer site. Also, a switchable intermediate conveyor is provided, which bypasses the buffer and which is in conveying connection with the first and second conveyors via a respective second transfer site.

Apparatus and computer readable media for managing an intelligent field, are provided. An exemplary apparatus can include hydrocarbon well instruments, a SCADA system, a process integration server and / or dynamic field data analyzing computer, and memory / computer readable media storing a dynamic field data analyzing computer program. The computer program can include instructions that when executed cause the dynamic field data analyzing computer to perform various operations to include receiving real-time dynamic field data, analyzing validity of the dynamic field data, validating values of the field data, validating a state / condition of a well, and flagging well components, well conditions, and / or well state validation issues.

A torque converter check valve has a valve element movable between a closed position and an open position by applying hydraulic pressure to a portion of the valve element and by applying a resilient force by a resilient element acting on another portion of the valve element. A spacer element is provided to act on the valve element and limit movement of the valve element in the direction in which the resilient element is compressed to reduce wear on the resilient element during operation of the torque converter check valve.

A multi-pole synchronous pulmonary artery radiofrequency ablation catheter may comprise a control handle, a catheter body and an annular ring. One end of the catheter body may be flexible, and the flexible end of the catheter body may be connected to the annular ring. The other end of the catheter body may be connected to the control handle. A shape memory wire may be arranged in the annular ring. One end of the shape memory wire may extend to an end of the annular ring and the other end of the shape memory wire may pass through a root of the annular ring and be fixed on the flexible end of the catheter body. The annular ring may be provided with an electrode group. The device possesses advantages of simple operation, short operation time and controllable precise ablation. The device can be used to treat pulmonary hypertension with pulmonary denervation.