The invention relates to the technical field of medical instruments, in particular to a spatial translation type surgical instrument vehicle with two handles fast to locate. The vehicle is formed by an instrument platform, a base table, a rod shaft, a base, a locating shaft, a locating plate, a stand column, an arc groove, an arc bar, the handles, a vehicle body, wheels, a beam and a balance adjusting rod. The balance adjusting rod is composed of a telescopic rod, a blind hole, a spring, a sleeve rod shaft, a sleeve rod and a weight handle. The sleeve rod is a rod body with the rectangular section. The top end of the sleeve rod is provided with the longitudinal blind hole. The telescopic rod is vertically inserted into the blind hole. The side face of the bottom end of the telescopic rod is provided with a ring-shaped protrusion. The stand column on the front side is welded with the beam horizontally arranged. The middle of the beam is provided with the sleeve rod shaft, wherein the beam and the sleeve rod shaft form a whole. The right end of the beam is provided with the arc bar, wherein the beam and the arc bar form a whole. The arc groove is formed in the arc bar.