10 results about "Antibiotic susceptibilities" patented technology

Systems and methods for the detection of sepsis and treatment of patients. A sepsis detection system includes a first subsystem configured to detect the presence of an infection in a patient, a second subsystem configured to detect the presence of a dysregulated immune response in the patient, a third subsystem configured to detect organ dysfunction in the patient, a fourth subsystem configured to detect antibiotic resistance (ARB) of a pathogen in the patient, and a processing device. The first, second, third, and fourth subsystems and the processing device are communicatively coupled to each other via a network. The processing device is configured to determine the presence of sepsis in the patient based on the presence of infection, the presence of the dysregulated host response, and clinical data indicative of organ dysfunction in the patient.The subsystems utilize at least one polymerase chain reaction (PCR) procedure, Raman spectroscopy, clinical data, electronic health record (EHR) data, and antibiotic susceptibility testing (antibiogram).

The present disclosure relates to a method of determining antibiotic susceptibility of a micro-organism in a sample, the method including: receiving the sample containing the micro-organisms; incubating at least one first portion of the sample with at least one antibiotic and at least one second portion of the sample with no antibiotic; extracting nucleic acid from the at least one first portion of the sample and the at least one second portion of the sample, wherein the nucleic acid is associated with the micro-organisms present in the sample; amplifying the extracted nucleic acid from the at least one first portion and the at least one second portion of the sample; and obtaining the antibiotic susceptibility information associated with the micro-organism from the amplified nucleic acid from the at least one first portion and the at least one second portion of the sample.

Provided herein are methods of determining antibiotic susceptibility of bacteria. In some embodiments, the methods include obtaining a series of images from partitioned samples over a length of time using a large volume scattering imaging (LVSi) technique to produce a set of image data. In some embodiments, the methods include extracting multiple phenotypic features from individual bacterial cells in the partitioned samples in parallel with one another and detecting one or more phenotypic feature changes associated with bacterial growth and response to the antibiotics in the set of image data over a selected period of time to produce a set of extracted phenotypic features, and passing the set of extracted phenotypic features through a trained machine learning model that predicts the identity and the antibiotic susceptibility of the bacterial cells in the partitioned samples. Related kits, devices, systems, computer readable media, and additional methods are also provided.

1. Name of the product in this design: Operation display unit of a cascaded graphical user interface for microbial antibiotic susceptibility testing of an electronic device. 2. Purpose of this design: An electronic device. 3. The key design features of this product are: the content that the graphical user interface requires protection for. 4. The picture or photo that best illustrates the key design points: Design 1 front view. 5. Design 1 is designated as the basic design. 6. Uses of the graphical user interface: Overall use of the interface: For microorganisms in patient samples, clinicians use the interface to identify drugs that the microorganisms are susceptible to, build cascades for candidate drug families, and create multiple tiers if the microorganisms show resistance to drugs in the previous tier. The part of the interface is the operation display section of the cascaded graphical user interface. The buttons on the left side of the interface allow users to add new cascades and view existing cascades; the two buttons in the upper right corner allow users to delete and save cascades; users can enter the cascade name in the first rectangle from the left at the top, select the biological interpretation group by clicking the second rectangle, and select the style type by clicking the third rectangle; users can select a specific drug by clicking the "Select drug" rectangle in the interface, add a new drug family by clicking the rectangle with the "+" symbol on the right; and add a new cascade by clicking the "+" rectangle at the bottom. After a user clicks the "Select drug" rectangle in the main view of Design 1 to select a drug, the interface changes to Design 1's modified state diagram 1. The user can then click the delete icon to the right of the name to delete the drug. After the user clicks the "Select drug" rectangle below Drug Family 1 in Design 1's modified state diagram 1, the interface changes to Design 1's modified state diagram 2. After the user clicks the rectangle with a "+" symbol in the middle right of Design 1's modified state diagram 2, the interface changes to Design 1's modified state diagram 3. After the user clicks the "Select drug" rectangle below Drug Family 2 in Design 1's modified state diagram 3, the interface changes to Design 1's modified state diagram 4. After the user clicks the rectangle with a "+" symbol in the middle right of Design 1's modified state diagram 4, the interface changes to Design 1's modified state diagram 5. After the user clicks the rectangle with a "+" symbol at the bottom of Design 1's modified state diagram 5 to add a new cascade, the interface changes to Design 1's modified state diagram 6. After the user clicks the "Select" rectangle in the second cascade of Design 1's modified state diagram 6... After selecting a drug using the "drug" rectangle, the interface changes to Design 1, state diagram 7. When the user clicks the rectangle with the "+" symbol at the bottom of Design 1, state diagram 7, to add a new cascade, the interface changes to Design 1, state diagram 8. The change process of Design 2 is the same as Design 1. 7. Other matters to be noted: The dotted line part of the figure is not claimed.

Disclosed are an antibiotic susceptibility testing device and a method thereof, in which before the testing device is activated to carry out testing, a growth recognition light source is operated to illuminate culture elements, and a light inspection module receives a growth message obtained from the number of the original specimen so as to determine if cultivation is completed. Then, the specimen is diluted and introduced into reaction receptacles of a reagent disc, of which the entirety is placed into an inspection setup tank to start the testing. After reaction, first and second inspection light sources of different wavelengths are sequentially applied to illuminate the same reaction receptacle. And, finally, a spectrum processing module converts a color message obtained from an AST-dedicated indicator into a wavelength message, to thereby obtain the result of inspection.

According to one aspect of the present invention, an electronic device for performing antibiotic sensitivity detection of a microorganism may comprise: a processor for: obtaining antibiotic data, the antibiotic data being data measured according to a change in an electrical characteristic of a target microorganism under antibiotic treatment; judging whether the antibiotic data is positive or negative, and inputting the positive control group data, the negative control group data and the antibiotic data of the target microorganism into a trained deep learning model, the deep learning model judges whether the antibiotic data is positive or negative according to the positive control group data, the negative control group data and the antibiotic data of the target microorganism; and identifying antibiotic sensitivity information of the target microorganisms according to different antibiotic types and concentrations by using the judgment result.

Disclosed are a sensing device and a method for diagnosing antibiotic susceptibility using same. The sensing device, according to one aspect of the present invention, may comprise an accommodation module, a first plate member, and a second plate member. The method for diagnosing antibiotic susceptibility, according to another aspect of the present invention, may comprise the steps of: (a) coating a sensor with an antibiotic; (b) injecting a fluid containing a microorganism into the accommodation module; and (c) detecting an electrical signal of the fluid to diagnose susceptibility of the microorganism to the antibiotic.

The invention relates to a reagent disc structure for antibiotic susceptibility testing, comprising a test holder (1), at least two support and positioning parts (112), a central injection portion (2), several microflow channels (3), several reaction receptacles (4), several preloaded reagents (41) for antibiotic susceptibility testing, several overflow channels (5), several overflow sumps (6), several narrowing portions (51), and several vent holes (7). Before packaging, the reaction receptacles (4) of the test holder (1) are preloaded with lyophilized preloaded reagents (41). A user can directly position the test holder (1) in a test device after injecting the sample into the central injection portion (2).During activation, the sample is subjected to centrifugal force, causing it to flow uniformly through the microflow channels (3) into the reaction receptacles (4). Figure for the abstract: 1.

A method for the determination of antibiotic susceptibility through stimulated Raman scattering microscopy is disclosed. The method utilizes a imaging apparatus adapted to collect a laser signal through a sample having a bacteria for imaging the metabolism of the sample. The sample can be manipulated with an antibiotic for imaging to determine the susceptibility of a bacteria to the provided antibiotic.

An antibiotic susceptibility testing reagent disc structure includes a test carrier, at least two supporting and positioning portions, a central injection portion, a plurality of micro flow channels, a plurality of reaction receptacles, a plurality of preloaded reagents for AST, a plurality of overflow channels, a plurality of overflow troughs, a plurality of narrowing portions, and a plurality of vent holes. Before packaging, the reaction receptacles of the test carrier are preloaded with freeze-dried preloaded reagents. A user can directly position the test carrier in the testing device after injecting the specimen into the central injection portion. Upon activation, the specimen is acted upon by the centrifugal force to evenly flow through the micro flow channels into the reaction receptacles. For an amount of specimen contained in the reaction receptacles is larger than the volume thereof, it flows along the overflow channels into the overflow troughs.