The invention discloses a design of a full pipeline of a single precision floating point multiplication-add fused unit, which realizes multiplication-add operation in the form of A+B x C. the multiplication-add operation is realized in the following five pipelines: in the first stage pipeline, exponential difference is calculated and a part of the multiplication is completed; in the second stage pipeline, A and B x C are aligned according to the exponential difference, effective subtraction and complement are performed, the rest multiplication is completed, simultaneously, the exponent is divided into six states, and the calculation method of normalized shift amount in different states are different; in the third stage pipeline, the number of leading zero is pre-estimated, simultaneously the sign of the final result is synchronously pre-estimated, and finally first stage normalized shift is performed; in the fourth stage pipeline, second normalized shift is performed first, and then addition and a part of half adjust are performed; in the last stage pipeline, addition and half adjust are completed, exponential terms are amended, and third stage normalized shift is completed in the spacing of the half adjust. The invention has the advantages that high performance and high precision are realized in the condition of low hardware cost.