The invention discloses an adjustable gain audio power amplification circuit which comprises an input unit, an audio amplification unit, a gain adjusting unit, a control unit, a comparison unit and an output unit, wherein the audio amplification unit is connected with the input unit, the gain adjusting unit is connected with the audio amplification unit, the control unit is connected with the gain adjusting unit, the comparison unit is connected between the gain adjusting unit and the control unit, and the output unit is connected with the audio amplification unit; the comparison unit compares an output signal of the output unit with a common-mode reference voltage and outputs a gain adjusting control signal to the control unit, and the gain adjusting control signal is inversed when the output signal of the output unit is equal to the common-mode reference voltage; when detecting that the gain adjusting control signal is inversed, the control unit transmits a received gain adjusting signal to the gain adjusting unit; then, the gain adjusting unit controls the gain of the adjustable gain audio power amplification circuit according to the received gain adjusting signal. The adjustable gain audio power amplification circuit disclosed by the invention is simple in structure, and cracking noise generated by gain adjusting is avoided.