The invention provides a cross folding device used for handkerchief paper packaging, and an implement method thereof. The device comprises a friction roller, a cut-off knife base, a cut-off knife roll, a paper absorbing roll, a first folding roll, a first folding paper pressing roll, a second folding roll, a second folding paper pressing roll, a transferring roll, a front side plate, a rear side plate, and a plurality of bearings. Handkerchief paper enters the device through the friction roller, and the handkerchief paper passes through the cut-off knife base, the cut-off knife roll, the paper absorbing roll, the first folding roll, the first folding paper pressing roll, the second folding roll, the second folding paper pressing roll, the paper absorbing roll, and the transferring roll in sequence. The cross folding implement method for handkerchief paper packaging comprises the following steps: 1) cutting paper in a transverse manner; 2) transmitting the handkerchief paper to the first folding roll; 3) folding the handkerchief paper for the first time; 4) performing handkerchief paper first folding paper pressing; 5) folding the handkerchief paper for a second time; 6) performing handkerchief paper second folding paper pressing; 7) and transferring the handkerchief paper. After the technical scheme is used, faults of a handkerchief paper production machine is reduced, production efficiency of handkerchief paper is improved, and mechanical automation of handkerchief paper production is improved.