The invention discloses a manufacturing method of safety fire-resistant medium and high voltage cables. The manufacturing method includes steps of selecting, drawing, annealing, conductor stranding, coextruding and covering of inner shield layers, insulating layers and outer shield layers, setting metal shield layers, isolated-phase extruding of fire-resistant isolated layers, lapping of first tape layers, cabling stranding and cabling tape lapping, extruding of oxygen isolating layers, extruding of fire-resistant isolating layers, lapping of second tape layers, lapping of metal armor layers, lapping of third tape layers and extruding of outer sheath layers. The medium and high voltage cables manufactured by the method have good heat insulation effect when laid on buildings, fire resistance of the cables is improved greatly, damages to an electric power system due to accidents such as fires and natural disasters can be delayed, and time can be gained for rescue work.