The invention provides a single-guide-rail automobile glass lifting and lowering device of a brand-new structure form. The single-guide-rail automobile glass lifting and lowering device comprises a reel, a guide wheel, an upper and lower steel wire rope, sliding blocks and an output motor, wherein the upper and lower steel wire rope is wound on the reel and the guide wheel; the sliding blocks arein sliding connection to the upper and lower steel wire rope; and the output motor is used for driving the reel to rotate. The single-guide-rail automobile glass lifting and lowering device also comprises an integral punching guide rail, wherein the integral punching guide rail comprises an automobile door metal plate installation interface, a guide wheel installation interface, a steel wire ropebracket installation interface and an output motor installation interface in sequence from top to bottom. Compared with a traditional glass lifting and lowering device, the invention is characterizedin that the guide rail integrates various functional interfaces, including an automobile door installation interface, the guide wheel installation interface, the steel wire rope bracket installation interface, the motor installation interface and the lie, parts, including a lifting and lowering device installation bracket, a steel wire rope bracket, a motor seat plate and the like, are reduced, assembling processes are simplified, the input of a production line is reduced while parts are reduced, production takt is quickened, and purchase cost and manufacture cost are greatly saved.