A motorcycle (10) is described, equipped with a rear drive wheel (12), rotatingly constrained to an oscillating arm (14) integral with the engine (16) of the motorcycle (10), at least one rear shock absorber (20), positioned between the oscillating arm (14) and the chassis (24) of the motorcycle (10), at least a first brake caliper (28) and at least a second brake caliper (32), acting on a single disc brake (36) fixed on the rim (38) of the rear drive wheel (12). The lower end (26) of the rear shock absorber (20) and the second brake caliper (32) are fixed to a plate (42) removably constrained to the oscillating arm (14) at one of its rear ends (14b). In this way, it is possible to have access to the rear drive wheel (12), and therefore remove it, without having to dismantle the second brake caliper (32) and relative transmission (34), thus facilitating the possible substitution of the wheel (12) or tire (46).