33results about How to "Simplify the implantation process" patented technology

A method of implanting a resilient self-molding annuloplasty ring including stretching it to an expanded diameter and attaching it to a heart valve annulus, then permitting the ring to contract to reduce the diameter of the annulus. The ring may be positioned on an insertion device that maintains the ring in its expanded diameter while attaching to the annulus. The resilient self molding annuloplasty ring which may be enlarged prior to implantation to facilitate implantation within a dilated or otherwise incompetent valve annulus having sufficient contractive force to render a valve competent. The self molding annuloplasty ring of the invention may further comprise integral attachment devices to aid in the implantation process.

A valve holder for a prosthetic valve having a stent with a stent base and multiple commissure posts projecting from the stent base, the valve holder including a central base portion, a plurality of legs radially extending from the central base portion, each leg comprising a first prong portion spaced from a second prong portion by a gap distance, a plurality of commissure post engaging members, wherein one commissure post engaging member is slideably engaged with each of the plurality of legs, and a handle extending from the central base portion.

A resilient self molding annuloplasty ring which may be enlarged prior to implantation to facilitate implantation within a dilated or otherwise incompetent valve annulus having sufficient contractive force to render a valve competent. The self-molding annuloplasty ring may further comprise integral attachment devices to aid in the implantation process. The resilient self-molding annuloplasty ring may be stretched to an expanded diameter and attached to a heart valve annulus, then permitted to contract to reduce the diameter of the annulus. The ring may be positioned on an insertion device that maintains the ring in its expanded diameter while attaching to the annulus.

A plurality of sensors are disposed in and around the heart of a patient to collect data such as various electrical parameters, pressure parameters and temperature parameters. The data collected via the sensors may be organized and stored according to cardiac rhythm type. The organization of data according to cardiac rhythm type allows the patient's physician to be better able to monitor how the various parameters are related to the various cardiac rhythm types. In a typical embodiment, one or more of the sensors may be deployed on a single lead implanted in the heart.

A valve holder for a prosthetic valve having a stent with a stent base and multiple commissure posts projecting from the stent base, the valve holder including a central base portion, a plurality of legs radially extending from the central base portion, each leg comprising a first prong portion spaced from a second prong portion by a gap distance, a plurality of commissure post engaging members, wherein one commissure post engaging member is slideably engaged with each of the plurality of legs, and a handle extending from the central base portion.

A valve holder for a prosthetic valve having a stent comprising a stent base and multiple commissure posts projecting from the stent base, the valve holder including a connector hub, a plurality of legs connected to the connector hub, each leg having an elongate portion and a commissure post engaging plate, a sliding member slideably connected to each leg of the plurality of legs and positioned between the connector hub and the commissure post engaging plates of the plurality of legs and slideably positionable at a first position relative to the connector hub with the commissure post engaging plates in an uncompressed configuration and a second position relative to the connector hub with the commissure post engaging plates in a compressed configuration, and a handle extending from the connector hub.

A valve holder assembly for delivering a prosthetic heart valve having a stent base an multiple extending commissure posts. The valve holder assembly includes a holder and a rotor that is rotatable relative to the holder.

A valve holder assembly for delivering a prosthetic heart valve having a stent base an multiple extending commissure posts. The valve holder assembly includes a holder and a rotor that is rotatable relative to the holder.

The invention relates to a microfluidic chip for multi-cell cocultivation and a preparation method thereof. Microstructures and microchannels are arranged on the surface of the microfluidic chip; under the driving of gravity which is generated by liquid difference, the implantation of different areas of the microchannels of multiple cells is realized by using the laminar phenomenon; and finally, the cocultivation of the multiple cells is realized, so that the foundation is laid for the research of cytobiology; the microfluidic chip is mainly applied in the related fields, such as cytobiology, genetics, drug screening and the like. The microfluidic chip realizes the cocultivation of the multiple cells, has the characteristics of intuition, convenience, miniaturization and low dosage of reagent and samples, and provides a brand new analysis technology for the multi-cell cocultivation.

The invention relates to a novel efficient micro-fluidic multi-cell co-culturing chip and a preparation method thereof. A microstructure and a micro-channel are arranged on the surface of the micro-fluidic chip; the surface of the micro-channel is decorated by bovine serum albumin; under the driving of gravity generated by liquid level difference between a solution inlet and a solution outlet, three cells are implanted in different regions of the micro-channel by using laminar flow phenomenon between liquid flows; finally, the three cells are co-cultured to lay a basis for studies on cell biology; and the novel efficient micro-fluidic multi-cell co-culturing chip provided by the invention is mainly applied to the related field of cell biology, genetics, drug screening and the like. Through adoption of the micro-fluidic chip, the three cells are co-cultured; the micro-fluidic chip has the advantages of intuitive property, convenience, miniaturization and low consumption of reagents and samples; and a brand new cell culturing and analyzing technology is provided for multi-cell co-culturing.

The invention relates to a micro-fluidic chip for high-efficiency medicine screening and a preparation method of the micro-fluidic chip. Two groups of microstructures and microchannels are formed on the surface of the micro-fluidic chip; two kinds of cells are fixed in respective specific cell culture areas; after the cells are paved in the culture areas fully, a medicine to be researched are added; the effects and the influence of the same medicine on the cells in the growth process of two kinds of cells are researched intuitively under a microscope; the curative effect of the new medicine on one cell and the toxicity of the new medicine on the other cell are screened; and new thinking and new research technology are provided for large-scale medicine screening. The micro-fluidic chip is mainly applied in the related fields of cytobiology, genetics, medicine screening and the like. The micro-fluidic chip is simple in operation, realizes in-situ culture of the two kinds of cells, reduces the using amount of reagents and samples, simplifies the cell implanting process, performs medicine screening efficiently, screens the curative effect of the new medicine on one cell and the toxicity of the new medicine on the other cell, has the characteristics of portability, economy, quickness and high efficiency, and provides a new analysis technology for large-scale medicine screening.

The invention discloses a 3D (three-dimensional) printing artificial cervical disc prosthesis which comprises a prosthesis upper end plate, a prosthesis lower end plate and a prosthesis nucleus pulposus. The prosthesis nucleus pulposus is arranged between the prosthesis upper end plate and the prosthesis lower end plate, the prosthesis upper end plate, the prosthesis lower end plate and the prosthesis nucleus pulposus are connected in a mutually matched manner, a first microporous surface is arranged on the upper surface of the prosthesis upper end plate, first inverted teeth are distributed on the first microporous surface, a second microporous surface is arranged on the lower surface of the prosthesis lower end plate, and second inverted teeth are distributed on the second microporous surface. The prosthesis nucleus pulposus comprises an elliptical base. The prosthesis has the advantages that the prosthesis is designed by reverse technology, design is completely bionic design, three-dimensional anatomic forms of the prosthesis end plates are completely fitted with those of vertebral end plates, grinding of the upper end plate and the lower end plate is almost omitted when the prosthesis is implanted, and completeness of the vertebral end plates is retained. The prosthesis can be rapidly manufactured by 3D printing technology, an implanting process can be simplified in practical application, surgical time is shortened, and surgical safety is improved.

The invention relates to a novel temperature response micro-fluidic cell culturing chip and a preparation method thereof. A microstructure and a micro-channel are arranged on the surface of the micro-fluidic chip; the surface of the micro-channel is decorated by bovine serum albumin molecule; under the driving of gravity generated by liquid level difference between a solution inlet and a solution outlet, cells are implanted in the micro-channel by using laminar flow phenomenon between liquid flows; finally, cell culture solutions with different temperatures are added from the solution inlet, so that the cells of the micro-channel are changed at different temperatures; therefore, the influence of temperature change on cell culture is studied and a basis is laid for studying cell biology; and the novel temperature response micro-fluidic cell culturing chip provided by the invention is mainly applied to the related field of cell biology, genetics, drug screening and the like. The micro-fluidic chip provided by the invention has the advantages as follows: the micro-fluidic chip is simple in operation, implantation and culture of the cells are finished, the consumption of reagents and samples is reduced, the cell implanting process is simplified, the influence of temperature change on cell culture is studied, the micro-fluidic chip is portable, economic, rapid, efficient and accurate, and a brand new cell culturing and analyzing technology is provided for studies on cell biology.

The invention relates to a micro-fluidic cell culturing chip and a preparation method thereof. A microstructure and a micro-channel are arranged on the surface of a micro-fluidic chip; two cells are respectively fixed in specific cell culturing regions; signal transmission and interaction between the cells are carried out between the cells through the micro-channel; under a microscope, the interaction between the two cells in the growing process can be intuitively studied and metabolites in the cell growing process are analyzed; a new idea and a new research technique are provided for researches on the cell biology, and the micro-fluidic cell culturing chip is mainly applied to the related field of cell biology, genetics, drug screening and the like. Through adoption of the micro-fluidic chip, co-culturing of the two cells is achieved, the operation is simple, parallel implantation and co-culturing of the two cells are realized, the usage amounts of reagents and samples are reduced, the cell implanting process is simplified, the interaction between the two cells in the growing process can be intuitively studied under the microscope, the metabolites in the cell growing process is analyzed and a brand new analysis technology is provided for researches on the cell biology and the micro-fluidic cell culturing chip provided by the invention is portable, economic, rapid, efficient and accurate.

The invention discloses a biodegradable lacrimal duct embolus and a preparation method thereof. The lacrimal duct embolus is prepared by using one or more of a lactide / caprolactone copolymer, a glycolide / caprolactone copolymer, a lactide / dioxane ketone copolymer and a lactide / trimethylene carbonate copolymer as raw materials through the following steps of sequentially carrying out melt extrusion,hot stretching and cold cutting on the raw materials in an inert gas atmosphere. The biodegradable lacrimal duct embolus is used for treating dry eye syndromes; in the process of operation, a part ofthe lacrimal duct embolus is implanted into a lacrimal duct, and the rest of the lacrimal duct embolus can automatically be shrunk into the lacrimal duct, therefore, in the process of operation, a patient feels no pain, the diameter of the lacrimal duct of the patient is not required to be measured before operation, and the lacrimal duct embolus in one product specification can be suitable for the lacrimal ducts in different sizes; in the process of preparing the biodegradable lacrimal duct embolus, the embolus can load anti-inflammatory agents, antibiotics and antiproliferative drugs so as to avoid the generation of complications such as inflammations, wrapping and the like; and in addition, the lacrimal duct embolus is good in biocompatibility and can be completely biodegraded in the lacrimal duct, and the final products of the embolus are non-toxic water and carbon dioxide, thereby avoiding secondary surgery of the patient.

The invention relates to a reagent concentration responsive microfluidic cell culture chip and a preparation method thereof. A microstructure and a microchannel are arranged on the surface of the microfluidic chip; the surface of the microchannel is modified by using bovine serum albumin cells; the cells are implanted in the microchannel by utilizing the laminar flow phenomenon between liquid flow under the drive of gravity generated by liquid difference between a solution inlet and a solution outlet; and cell culture solutions of biological reagents with different concentrations are added into the solution inlet at last. The microfluidic chip can be used for making a research on the influence of reagent concentration change on cell culture so as to lay a foundation for cell biology research, and is mainly applied to the related fields of cell biology, genetics, drug screening and the like. The microfluidic chip is simple to operate, can be used for finishing cell implantation and culture, reducing the usage amount of reagents and samples, simplifying the cell implantation process and making a research on the influence of reagent concentration change on cell culture, and has the characteristics of being portable, economic, quick, efficient and accurate, thereby providing a brand-new cell culture and analysis technology for cell biology research.

The invention relates to a novel drug screening microfluidic chip and a preparation method. A microstructure and a micro channel are arranged on the surface of the microfluidic chip. Two types of cells are fixed in respective cell culture areas respectively. When the cells fill the cultivation areas and drugs are added, the reaction of cells to drugs during the process of growth can be visually researched with a microscope, as a result, a new thought and a new research technique for large-scale drug screening are provided. The novel drug screening microfluidic chip and the preparation method are applicable to fields relevant to cell biology, genetics, drug screening and the like. The microfluidic chip is simple to operate, achieves in-situ cultivation of cells, reduces the dosage of agent and samples, simplifies cell implantation process, effectively achieves drug screening, has the characteristics of portability, economy, high speed and high efficiency, and provides a novel analyzing technology for large-scale drug screening.

A silicene electronic device includes a silicene material layer. The silicene material layer of the silicene electronic device has a 2D honeycomb structure of silicon atoms, is doped with at least one material of Group I, Group II, Group XVI, and Group XVII, and includes at least one of a p-type dopant region doped with a p-type dopant and an n-type dopant region doped with an n-type dopant. An electrode material layer including a material having a work function lower than the electron affinity of silicene is formed on the silicene material layer.

The invention discloses a biodegradable magnetic control PVA micro-motor stent and a preparation method and use of the biodegradable magnetic control PVA micro-motor stent. A magnetic control PVA material is obtained by mixing and cross-linking polyvinyl alcohol, magnetic particles, a cross-linking agent and water. An intravascular stent prepared from the material can adopt ultrasonic waves to trigger shape memory, an adjusting process and an implantation process of a material formula can be simplified in cooperation with a movement performance of a magnetic drive motor, the intravascular stent is controlled to move in vivo to reach a target position, a fixed-point implantation is not needed, invasiveness and implantation risks are further reduced, and the stent better meets actual application requirements.

The invention discloses a solder ball with a coating, a ball mounting method and a packaging method. The solder ball with the coating comprises a solder ball body, a soldering flux coating is arrangedoutside the solder ball body, and a hot melting protective coating is arranged outside the soldering flux coating. During ball mounting, the method comprises: firstly forming the solder balls with the coatings; placing the solder ball with the coating on a bonding pad of a substrate; and carrying out reflow soldering on the solder ball with the coating and the bonding pad. The spot welding link is omitted, the solder ball implantation process is simplified, and the efficiency is high.

A device for supplying energy to hydraulically or pneumatically actuated active implants. The device can take the form of pumping systems, metering systems, and / or occlusion systems. The device comprises a receiving coil for generating an electric voltage due to a changing magnetic flux that is generated by an extracorporeal transmitting coil. The receiving coil is designed such that said coil can be implanted into subcutaneous tissue. Furthermore, an electric line is provided for transmitting the electric current that is generated by the receiving coil from the receiving coil to the active implant. The device further comprises a compensation container for temporarily receiving a transmitter fluid, by means of which the active implant is activated. The compensating container is mounted on the receiving coil and / or on the electric line such that the compensating container together with the receiving coil and / or the electric line can be implanted into a common tissue or muscle pocket in the body of a patient.

The invention discloses an asymmetric artificial aortic valve using eccentric limiting keys for intervention. The asymmetric artificial aortic valve comprises an asymmetric straight-barrel-shaped short stent main body containing a valve leaflet structure and an eccentric limiting component fixed on the outer side of the stent main body through a single connecting point. The stent main body with the valve leaflet is used for replacing the original diseased valve. The eccentric limiting structure fixed on the outer side of the stent in a single point mode is used for adapting to the position of an implantation system to naturally guide positioning of the main stent valve and providing support to prevent the main stent valve from sliding down.

The invention relates to a suture ring for a left ventricle. The suture ring is characterized by comprising a medical stainless steel clamp sleeve and an annular terylene mat; the clamp sleeve comprises a clamp ring and a fixing ring body of the annular terylene mat, the clamping ring and the fixing ring body are integrally connected; the clamp ring is an integral clamp ring consisting of a semi-circular fixed ring and a thin-walled semi-circular movable ring; the upper part of the clamp ring is provided with a fastening groove; the upper port of the fixed ring, which corresponds to the fastening groove, is provided with a thread port; the upper port of the movable ring is provided with a screw through hole; the fixed ring is in threaded connection with the movable ring through a medical stainless steel fastening screw; and the annular terylene mat and the fixed ring body are fixedly connected integrally. The suture ring has the advantages that the defect of complex implantation process of the left ventricle in the conventional ventricle assisting device is overcome, and a centrifugal ventricle assisting device is divided into a blood pump main body and the suture ring for the left ventricle, so that a flowing inlet end of a centrifugal blood pump is connected with the left ventricle, and a flowing outlet end of the centrifugal blood pump is connected with aorta; and therefore, the assisting of the left ventricle can be realized, a circulatory function is improved, and a patient suffering from severe symptoms of heart failure can be treated. The implantation processes of the blood pump and the ventricle are simplified, and the safety of operation is improved.

The invention provides an auxiliary tool for assisting the installation of an implant of a heart chamber. The auxiliary tool is used for implanting a sewing ring assembly and comprises a left clamp and a right clamp, which are matched with each other in a clamping manner, the end parts of the left clamp and the right clamp are correspondently provided with a guide rail and / or guide groove for limiting the clamping position of the left clamp and the right clamp, and the left clamp and the right clamp are respectively provided with an arc which is matched with an arc of a lantern ring of a sewing ring in a positioning manner. The auxiliary tool is used for positioning the sewing ring when in heart operation, so that a doctor can cut the heart and installing an insertion blood pump through a single hand, the blood pump heart implanting process is simplified, and the surgical safety is improved; moreover, the auxiliary tool is simple in structure, convenient to operate, low in surgical difficulty and short in operation time.

The present disclosure provides a multi-directional implantable flexible electronic device and a manufacturing method thereof, wherein the multi-directional implantable flexible electronic device includes: at least one composite magnetic film device and a column core connected thereto; a composite magnetic film device with a custom magnetic field distribution The magnetic film device has a coiled structure, and the coiled structure is fixed by a water-soluble polymer or a fixing device; the composite magnetic film device includes: a magnetic film and a flexible electronic device attached to the magnetic film. After the implantable flexible electronic device is implanted in the predetermined area, the water-soluble polymer is hydrolyzed or the fixing device is opened, and the composite magnetic film device in a coiled structure is released and fully unfolded into a flat structure. The present disclosure can implant flexible electronic devices in a limited space, expands the application scene, and can simultaneously implant multi-directional, multi-quantity, and multi-functional devices through a single small-diameter opening window, effectively simplifying the implantation process, and avoiding problems caused by large apertures. , The risk of implantation caused by a large number of perforated windows.