The invention discloses a high-effective fertilizer for improving greensickness resistance of tomatoes. The fertilizer includes, by mass, 0.1-0.5 parts of a sterilizing agent, 5-8 parts of a traditional Chinese medicine agent, 2-4 parts of s-adenosylmetionine, 2-4 parts of diammonium phosphate, 2-4 parts of nitrohumic acid, 15-20 parts of banyan leaves, 3-8 parts of soluble small-molecular chitosan, 12-15 parts of chestnut shell powder, 15-20 parts of animal feces, 3-5 parts of starch microspheres, 0.2-1 part of a microelement additive, 10-15 parts of corncob, 2-5 parts of zinc aminodithioformate, 1-3 parts of borax, 1-3 parts of magnesium sulfate, 1-3 parts of potassium chloride, 20-30 parts of pond sludge, 10-15 parts of plant ash, 13-15 parts of rotten fruits, and 60-90 parts of water.In the invention, gibberellins, 24-epibrassinolide and sodium hypochlorite are subjected to dispersion treatment under ultrasonic wave with the soluble small-molecular chitosan and the starch microspheres, thus producing the sustained-releasing disease control factor which is easy to absorb and utilize. In the fertilizer, the sustained-releasing disease control factor can be absorbed and utilizedfor a long time during growth of tomatoes, thus avoiding increase of planting labor quantity due to repeated fertilization. Meanwhile, resistance of the tomatoes against the greensickness is improved.