The invention discloses a universal three-dimensional picture synthesis method based on lenticular grating LCD (liquid crystal display) free three-dimensional display device, comprising the following steps: 1) measuring the actual lines LPI value and actual elevation angle Alpha value of the lenticular grating; 2) carrying out sampling on N viewport pictures according to the required viewport number N and resolution factor H*V of synthesizing three-dimensional pictures, the vertical resolution factor of each viewport image being sampled to be V/v, and the horizontal resolution factor being sampled to be H/h, wherein, N is more than or equal to 2, v*h is equal to N, and v is an integral value mostly close to N; 3) filling the RGB (red, green, blue) components of N sampled viewport pictures in the RGB components of the three-dimensional pictures according to the actual lines LPI value, the actual elevation angle Alpha value and the dot pitch DOT of an LCD display so as to obtain the required three-dimensional pictures. The universal three-dimensional picture synthesis method is applied to lenticular grating with random lines LPI value and random elevation angle Alpha value, and can quickly and accurately synthesize three-dimensional pictures with random viewport numbers and random resolution factor.