45 results about "IMMUNOLOGIC DEFICIENCY" patented technology

The present invention relates to a kind of cyclopeptide derivative containing natural or artificial amino acid substituted active thymosin alpha-1 segemnt, and its preparation process, medicine composition and their medicines for treating or preventing diseases related to immune deficiency, hypoimmunity, etc.

The invention discloses a green feed additive and a preparation method thereof. The green feed additive is prepared by mixing the following components in portion by weight: 40 to 60 portions of cortex eucommiae extract, 10 to 20 portions of streptococcus faecalis powder, 30 to 40 portions of polysaccharide peptide powder and 8 to 20 portions of folium cortex eucommiae finemeal, wherein the cortex eucommiae extract at least contains 0.2 percent of chlorogenic acid; the polysaccharide peptide powder is prepared by concentrating, decoloring, precipitating with alcohol and drying the ferment liquid which is obtained by fermenting the streptococcus faecalis powder. The components of the invention are integrally applied, which can remarkably improve the function of an animal immune system, strengthen disease preventing ability of organism, and resist the intrusion of pathogen; the green feed additive contains virus resisting the immunodeficiency which can bidirectionally adjust the function of cellular immunity and greatly improve the survival rate of feeding animals; and under the conditions without hormone, the green feed additive can promote the growth and breed of animals, greatly improve the quality and taste of eggs and meat, and keep the meat quality more fresh and more close to wild taste.

The present invention relates to active fragment of natural or artificial amino acid substituted thymosin alpha-1 and its polyethylene glycol derivatives, their preparation process, the medicine composition containing them, and their application in the medicine for preventing and treating diseases related with immune deficiency and hypoimmunity, including hepatitis B, hepatitis C, malignant melanoma, non-small cell lung carcinoma, SARS, etc.

Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a recombinant cell comprising at least one NFAT regulator protein or fragment or derivative thereof, assessing the effect of the test agent on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, and identifying the test agent that has an effect on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, whereby the identified test agent is characterized as an agent that modulates an NFAT regulator protein. Methods of identifying an agent that modulates intracellular calcium, methods to screen for an agent that modulates NFAT regulator function, methods to diagnose unexplained immunodeficiency in a subject, and methods for identifying an agent for treating or preventing a disease or disorder associated with a NFAT regulator protein or calcium signaling are also disclosed.

The present invention discloses an alopecia-stopping hair-growing preparation which can be used for curing alopecia resulted from various causes, specially for effectively curing alopecia seborrhoeica, immunologic deficiency alopecia and alopecia due to chemotherapy. It is made up by using thymic peptide, nettle extract, ginkgo leaf extract, vitamin E acetate, preservative, isopropanol, ethyl alcohol and water according to a certain mixing ratio. Said invention also provides its preparation method.

The present invention relates to a kind of cyclopeptide derivative containing natural or artificial amino acid substituted active thymosin alpha-1 segment, and the preparation process thereof, medicine composition and their medicines for treating or preventing diseases related to immune deficiency, hypoimmunity, etc.

The present invention provides methods for restoring and increasing dendritic cell populations in a subject by modulation of the lymphotoxin-β receptor (LTβR) via LTβR agonists. The invention also provides methods for screening for agents capable of restoring or increasing dendritic cell populations. The invention further provides a method for the treatment of immunodeficiency by administration of an LTβR agonist.

The present invention relates to pharmaceutical compositions of calanolides, their derivatives and analogues, and process for producing the same having enhanced solubility and bioavailability for oral or parenteral administration. The invention further provides for a method of using the disclosed compositions for the treatment and prevention of retroviral diseases such as human immunodeficiency, specifically HTV-1 and mycobacterial diseases especially tuberculosis infections in mammals, particularly humans.

The invention discloses a highly metastatic model of human melanoma, a highly metastatic cell subline of the human melanoma, creation methods for the highly metastatic model and the highly metastatic cell subline, and the dynamic detection of metastasis. The subcutaneously-transplanted mouse highly metastatic model and the corresponding cell subline are established in an in-vivo screening way in a mouse with severe combined immune deficiency (SCID) by using mouse lung metastasis, namely human malignant melanoma cell strain A375 pulmonary metastasis, wherein the highly metastatic cell subline of the human melanoma is A375sci, and has a human tumor cell karyotype; and 60 to 75 hypo-triploid-dominated chromosomes are acrocentric and have a heteroploid karyotype. The cell subline has the two routes of metastasis of blood trails and lymph. The in-vivo screening of the highly-metastatic model is performed by using animals with severe immune deficiency, and is expressed and applied in nude mice. A method for detecting Alu genes by using a polymerase chain reaction (PCR) method is simple, highly sensitive and highly specific, and can be used for detecting organ metastasis, particularly micrometastasis, in a human tumor animal-xenotransplantation model.

The invention relates to a quick detection kit for detecting human immunologic deficiency disease (HIV) using nm immunomagnetic beads, related to biology applied technique field. The detected sample is added on the sampling pad of the test paper from the sampling hole and the sample dissolves the mark beads and chromatography is performed on the NC membrane, and then the data on the test paper isdetected using magnetic force detector in preset time and the result is decided based on the read data. The kit is used for screening or clinical diagnosis of the HIV infection with high sensitivity,specificity, quickspeed, convenience and suitable for detection on site and real time recording and storing the result.

The invention discloses a ceratopteris pteridoides gene for resisting human immunologic deficiency disease toxoprotein congeners, and a preparation method and application thereof. The preparation method comprises the following steps: 1, extracting total DNA by using an improved CTAB method, and preserving; 2, amplifying the intermediate segment of the ceratopteris pteridoides gene for resisting human immunologic deficiency disease toxoprotein congeners; 3, amplifying 5' flanking sequence of the ceratopteris pteridoides gene for resisting human immunologic deficiency disease toxoprotein congeners; 4, amplifying 3' flanking sequence of the ceratopteris pteridoides gene for resisting human immunologic deficiency disease toxoprotein congeners; and 5, recycling and cloning the PCR product: recycling the intermediate segment of the target gene, and 5' and3' flanking sequence segments, transforming, culturing and selecting white colonies; and 6, judging the clone, measuring the sequence and splicing. The gene can be used for regulation and control on expression of potential antivirus genes in plant research, carrying out research into plant antivirus gene engineering, and further establishes a ceratopteris pteridoides CVNH protein preparation system, thereby finally realizing large-scale industrial production.

A multi-chimeric cell created by the ex vivo fusion of three or more hematopoietic stem cells, mesenchymal stem cells, myoblasts, pericytes, or satellite cells, or a combination thereof, from three ormore different donors is provided, as well as the use of these cells in thransplant therapy and treatment of immune deficiency and genetic disorders.

The invention provides a composite for preparing the pluripotent stem cells of a mammal with high immunodeficiency, such as a mouse, in a high efficient and stable mode, a method of applying the composite, a reagent box containing the composite and the application thereof. The composite comprises stem cell basic culture media and vitamin C or vitamin C ramification.

A compound represented by formula (I):(wherein the symbols are the same as defined in the description), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medicinal use thereof.The compound represented by formula (I) has CXCR4 antagonistic activity. It is hence useful as, e.g., a preventive and / or therapeutic agent for CXCR4-mediated diseases such as inflammatory / immunologic diseases (e.g., rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, and rejection reactions of transplanted organs), allergic diseases, infections diseases (e.g., human immunodeficiency virus infection and acquired immunologic deficiency syndrome), psychoneurotic diseases, cerebral diseases, cardiac / vascular disease, metabolic diseases, cancer diseases (e.g., cancer, cancer metastasis) or as an agent for regeneration therapy.