The invention discloses a plaster for treating pain of the neck, shoulders, waist and legs. The plaster is prepared from 5 g of flos carthami, 5 g of radix notoginseng, 5 g of herba saussureae involucratae, 5 g of frankincense, 5 g of myrrh, 5 g of zaocys dhumnade, 5 g of semen strychni, 5 g of scorpions, 5 g of resina draconis,5 g of centipedes, 5 g of geckos, 5 g of crude radix aconitum carmichaelii, 5 g of crude radix aconiti kusenzoffii, 5 g of herba asarum heterotropoides, 3 g of rhizome drynariae, 1 g of nidus vespae, 3 g of cortex cinnamomi, 3 g of cortex eucommiae, 5 g of manyleaf paris rhizome, 2 g of radix angelicae sinensis, 4 g of rhizoma chuanxiong, 4 g of herba lycopodii, 4 g of caulis spatholobi, 4 g of fructus chaenomelis lagenariae, 4 g of root-bark of monkshoodvine, 2 g of radix dipsaci, 2 g of radix clematidis, 1 g of leeches, 2 g of camphor and 1.5 g of borneol. The plaster has a remarkable treatment effect on cervical vertebra syndromes, the stiff neck, periarthritis of the shoulders, lumbar disc herniation, acute lumbar muscle sprain, lumbar posterior joint dysfunction, chronic lumbar muscle strain and the like, and solves the problems that existing plasters for treating the pain of the neck, shoulders, waist and legs have an ordinary effect and long treatment time.