The present invention relates to a combination of at least two components, component A and component B, component A being an AhR inhibitor and component B being pemmumab or Nasumab. Another aspect of the invention relates to a combination of three components, component A, component B and component C; the component A is an AhR inhibitor, the component B is pemmumab or Nasumab, and the component C is another agent. The invention further relates to the use of such a combination as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, the compounds are useful in the treatment or prevention of breast cancer, respiratory tract cancer, brain cancer, reproductive organ cancer, digestive tract cancer, urinary tract cancer, eye cancer, liver cancer, skin cancer, kidney cancer, head and neck cancer, thyroid cancer, parathyroid cancer, and their distal metastases, lymphoma, sarcoma and leukemia.