64 results about "Prevention breast cancer" patented technology

A method is described for preventing breast cancer recurrence after surgical removal of a breast cancer mass. Specifically, the method is thermal treatment of breast tissue surrounding a cavity after lumpectomy for breast cancer. Delivery of a heated fluid is through a balloon catheter to the cavity generated after lumpectomy with the goal of ablating the surrounding tissue, including transformed cells that were not removed through surgery. A balloon and controller were designed for this application.

Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.

Disclosed is a method for the prevention of and the reduction of risk of breast cancer and ovarian cancer in a female human subject by the administration of selenium (or its salts or derivatives).

The present invention is directed to compounds, compositions thereof, and the use of the compounds and compositions for the treatment and prevention of breast cancer. In one embodiment, the present invention relates to the use of a substituted triphenyl butene or prodrug thereof for the treatment of breast cancer in mono-therapy or in combination therapy, or for a reduction in the recurrence rate of previously-treated breast cancer.

Pharmaceutical compositions of 4-hydroxy tamoxifen, particularly compositions suitable for percutaneous administration, are useful in methods for treating and preventing breast cancer. When percutaneously administered to a patient's breasts, 4-hydroxy tamoxifen concentrates locally, and exerts an anti-estrogenic effect. In patients with breast cancer, this effect reduces tumor tissue proliferation. In patients at risk for developing breast cancer, the anti-estrogenic effect prevents breast tumor formation.

The present invention is directed to a system for treating individuals at risk of or suffering from breast cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains in a foreign nucleic acid encoding at least one breast cancer antigen.

An improved method and products for the hormonal treatment of breast cancer by breast implants of anti-estrogens and steroid hormones in formulations as fused with a lipoid carrier or encapsulated in microcapsules or in Silastic capsules is provided. Such breast implants renders a constant slow-release of their contents to the breast tissue for extended periods by biodegradation and diffusion. It facilitates higher breast tissue concentrations of anti-estrogen and hormonal compositions. Because of their high concentration in the breast and lower systemic distribution, tumor control is much improved and the their systemic toxicity is minimized. An added beneficial effect of these breast implants on breast cancer is mediated by the inhibition of hypothalamic-pituitary LHRH, FSH and LH secretion by these composition's systemic contents. It is also an effective prophylaxis against breast cancer. Furthermore, it reduces the cost of hormonal treatment of breast cancer. Anti-estrogen hormonal implants to the breast as concomitant hormonal treatment with conventional radiation therapy also facilitates improved tumor control and cure rates of breast cancer.

Provided herein are Pyrrolopyrimidine Compounds having the following structure:wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.

Aromatase inhibitors (AIs) are disclosed which are useful in the treatment and prevention of post-menopausal breast cancer. New AIs derived from natural products are disclosed that are evaluated for clinical utility for treating post-menopausal breast cancer and may also act as chemopreventive agents for preventing breast cancer. Several pure compounds demonstrated AI activity using a noncellular, enzyme-based microsomal and a cell-based aromatase assay. Correlations are made between structural classes with levels of aromatase inhibition. The disclosure may be utilized to direct synthetic modification of natural product scaffolds to enhance aromatase inhibition or to standardize botanical dietary supplements for increased aromatase inhibition activity.

The subject invention addresses the need for methods of treatment and prevention of breast cancer, and other cancers, by providing a peptide of eight to twenty amino acids in length which comprises a hydrophilic analog of an alpha-fetoprotein peptide having SEQ ID NO:6: EMTPVNPG. The peptides may be linear, but are preferably cyclic. The peptides may be provided as dimers or other multimers. A composition comprising the peptide, an antibody that specifically binds to the peptide, a method of reducing estrogen-stimulated growth of cells using the peptide, as well as a method of treating or preventing cancer, such as breast cancer, are also provided. The treatment or prevention method can include the use of tamoxifen therapy in combination with the peptide therapy.

The invention relates to the application of IL1R2 in prognosis evaluation and targeted therapy of breast cancer. Specifically, the invention provides the application of an IL1R2 gene, mRNA, cDNA, a protein or a detection reagent thereof, wherein the IL1R2 gene, the mRNA, the cDNA, the protein or the detection reagent thereof are used for (i) detecting breast cancer or risk of breast cancer and / ora marker for breast cancer metastasis or risk of breast cancer metastasis, and / or (ii) preparing a diagnostic reagent or a kit for detecting breast cancer or the risk of breast cancer and / or breast cancer metastasis or the risk of breast cancer metastasis. A study shows that the IL1R2 can serve as a therapeutic target of breast cancer. The invention also provides the application of an inhibitor containing IL1R2, and the inhibitor is characterized by being used for preparing (i) a pharmaceutical composition for treating breast cancer and / or (ii) a pharmaceutical composition for preventing breast cancer metastasis.

In certain aspects, the present invention provides compositions and methods for treating or preventing breast cancer in humans.

The present application relates to treating and / or preventing breast cancer, including locally advanced or metastatic, ER+, HER2− breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I),or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein.

It discloses compounds for the treatment and prevention of breast cancer, which are specifically 2-phenyl benzoselenazole compounds, pharmaceutically acceptable salts thereof and prodrugs thereof. The present invention further discloses pharmaceutical compositions containing the compounds and applications of the compounds in preparing medicines for the treatment and prevention of breast cancer in mammals. The compounds of the present invention can effectively inhibit or reduce the growth or proliferation of breast cancer cells in mammals, with no inhibition effect on the growth of part of the tested cell lines except for the breast cancer cell lines, and are highly selective.

Compounds of this formulaare useful for preventing breast cancer.

The present invention provides methods and compositions for treating or preventing breast cancer with S-equol. The method and compositions are particularly suited to treating triple-negative breast cancer. The S-equol may be administered alone or in combination with one or more cytotoxic or immunotherapeutic compound or molecule.

The invention provides a method for making health-preserving sweet potato biscuits and belongs to the technical field of the agricultural and sideline product processing. The method includes the following seven steps of grinding into thick liquid, processing, fermentation, material preparation, primary fermentation, secondary fermentation and baking and forming; glutinous rice flour can also be added in the secondary fermentation process, and during baking, reed leaves soaked by artemisia apiacea leaves are adopted; the health-preserving sweet potato biscuits have the advantages of adopting waste sweet potato residues left after starch is prepared and turning waste into treasures, and is capable of avoiding pollution discharge and improving the environment. The sweet potato residues are coarse fibers, after being eaten by people using fine foods for a long time, the sweet potato residues can promote the gastrointestinal motility, improve the health level and prevent occurrence of breast cancers and colorectal cancers; by adding camellia-seed oil in advance, the lubricating property of the sweet potato residue coarse fibers can be improved, and the taste is improved; white vinegar is used for fermentation, therefore, intestines and the stomach can better adsorb nutrient substances in the sweet potato residues and the camellia-seed oil, the fibers are softened and the taste is improved; during biscuit making, the raw materials are fermented by steps, the glutinous rice flour is added, the viscosity of noodles can be improved, the noodles are puffed moderately, and the made biscuits are crisp and soft and pleasant to the palate and have the health-care and health-preserving function.

The invention discloses a bra prepared from Chinese herbal medicines and used for preventing breast cancer, relates to medical supplies, and particularly discloses the bra prepared from the Chinese herbal medicines and prepared from 15 g of small centipeda herb, 12 g of cyperus rotundus root, 12 g of red peony root, 12 g of pericarpium citri reticulatae, 30 g of herba corydalis bungeanae, 30 g of angelica sinensis, 20 g of honeysuckle flower, 20 g of fructus forsythiae, 20 g of polygonum cuspidatum and other raw materials. Compared with a conventional general bra, the bra disclosed by the invention can give full play to traditional Chinese medicine traditional efficacies of soothing liver and strengthening spleen, resolving depression and promoting blood circulation, and softening hardness to dissipate stagnation, so as to play a role in prevention of breast cancer. In addition, the invention also provides a preparation method of the bra; the preparation method has the advantages of low cost and simple process, and is suitable for industrial batch production. The bra prepared from the Chinese herbal medicines and used for preventing breast cancer has the function of preventing breast diseases; the preparation method is simple and easy to implement, the cost of treatment is greatly reduced, the patient economic burden is reduced, and the bra has good prospects for development.

The invention provides breast cancer prevention equipment and a breast cancer prevention method, an overweight patient with breast cancer risk realizes weight loss by using the breast cancer prevention equipment, and further breast cancer is prevented. The breast cancer prevention equipment comprises a base, a main body of the base is of a rectangular structure, transverse grooves are formed in the bottom end face of the base, and the two transverse grooves are formed in the bottom end face of the interior of the base, so that the problem that during existing weight reduction exercise, sweat generated during exercise is difficult to remove synchronously is solved; in order to solve the problem that a user is inconvenient to exercise due to sweat accumulation easily in the prior art, a scraping plate slidably connected to the upper side of a base is pushed through expansion of a pop-up air pipe, and when the scraping plate moves along the base, sweat generated in the exercise process of the user can be rapidly scraped and discharged, so that the user can do exercise conveniently. Sustainability of weight reduction movement is realized.

The invention relates to a Maackia amurensis extract and the application thereof. The Maackia amurensis extract is prepared by the method including the following steps: heart wood, root cortices, stem barks, branch barks, leaves, leaf stalks, flowers, fruits and / or seeds of the Maackia amurensis are extracted by methanol or ethanol; the extracts are filtered and are concentrated and dried into extractum or dry powder; the extractum or the dry powder is catalyzed and hydrolyzed by inorganic acid, organic acid or enzyme; acid hydrolysate or enzymatic hydrolysate is obtained through extraction by aliphatic ester, methylene dichloride or methenyl chloride; and organic phase is concentrated to be dry to obtain the Maackia amurensis extract. The total content of isoflavone glycoside of the Maackia amurensis extract prepared by the method ranges from 15 percent to 85 percent. The invention also uses the Maackia amurensis extract as an estrogenic drug for preventing the breast cancer, the prostatic cancer, the colon cancer, the osteoporosis and the climacteric syndrome.

The present invention relates to a method for diagnosing breast cancer via bacterial and archaeal metagenomic analysis and, more particularly, to a method for diagnosing breast cancer by performing bacterial and archaeal metagenomic analysis by using a subject-derived sample, and analyzing an increase or decrease in the content of a specific bacterium or archaeon-derived extracellular vesicle. Anextracellular vesicle secreted from a bacterium or an archaeon present in the environment can be absorbed into the body and directly affect the occurrence of cancer, and breast cancer is difficult todiagnose early on before any symptom appears, which makes efficient treatment difficult. As such, through the bacterial and archaeal metagenomic analysis using a human body-derived sample according tothe present invention, the risk of the onset of breast cancer can be predicted in advance, enabling early diagnosis and prediction of a breast cancer risk group and delay of the time of the onset orprevention of the onset with proper care, and early diagnosis is still possible even after the onset, which can lower the incidence rate of breast cancer and enhance the treatment effect.

The invention discloses a breast cancer prediction method based on penalty COX regression, which comprises the following steps of: processing follow-up data into survival data for later use, taking all prediction factors after data preprocessing as input variables of a model, sampling through a bootstrap method to obtain T self-service sample sets, a penalty COX regression model is independently constructed on the basis of different self-service sample sets to serve as a base predictor of integrated learning, after the base predictors are constructed, a simple average method is used for combining the T base predictors, and finally an integrated penalty COX regression model is formed to serve as an integrated predictor for breast cancer incidence prediction. According to the breast cancer prediction method based on penalty COX regression, a unique structure of a Bagging integrated framework and a penalty regression model is adopted, and the relationship between different dimension factors and female breast cancer onset risks in China is favorably discussed, so that doctors are assisted to give suggestions for preventing breast cancer onset, the variance of an estimator can be reduced, and the prediction accuracy is improved. The instability of estimation of a single classifier is avoided, and the prediction performance is improved.

The present invention relates to a combination of at least two components, component A and component B, component A being an AhR inhibitor and component B being pemmumab or Nasumab. Another aspect of the invention relates to a combination of three components, component A, component B and component C; the component A is an AhR inhibitor, the component B is pemmumab or Nasumab, and the component C is another agent. The invention further relates to the use of such a combination as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, the compounds are useful in the treatment or prevention of breast cancer, respiratory tract cancer, brain cancer, reproductive organ cancer, digestive tract cancer, urinary tract cancer, eye cancer, liver cancer, skin cancer, kidney cancer, head and neck cancer, thyroid cancer, parathyroid cancer, and their distal metastases, lymphoma, sarcoma and leukemia.

The invention belongs to the technical field of molecular biology and genetic engineering, and relates to siRNA for reducing the expression of a THEM6 gene, a recombinant vector and application thereof. The siRNA specifically reduces the expression of the THEM6 gene. Since the siRNA is capable of specifically reducing the expression of the THEM6 gene, the siRNA can be applied to the preparation ofa drug for treating and / or preventing breast cancer.

Disclosed are a composition and a perfume composition for inhibiting growth of breast cancer stem cells containing phenylacetaldehyde or a pharmaceutically acceptable salt thereof as an active (effective) ingredient, and a pharmaceutical composition, a food composition or the like for inhibiting metastasis of breast cancer, or treating or preventing breast cancer, including the composition. The phenylacetaldehyde inhibits growth of breast cancer cells and formation of breast cancer stem cells. In addition, the phenylacetaldehyde inhibits expression of self-renewal genes such as Nanog, Sox2, Oct4, and CD44 known to be specifically expressed in breast cancer stem cells, inhibits production of IL-6 known to be involved in formation of mammospheres of breast cancer stem cells, and inhibits STATS signaling pathways. Accordingly, the compound inhibits growth of breast cancer stem cells and is useful for the treatment of breast cancer.