The invention relates to a novel structure of a drilling and milling machine tool, and the novel structure comprises a base, upright posts, a power head, a sliding worktable, a regulating base, circular arc-shaped slotted holes, a motor, a lead screw, an upper cross beam, a handwheel, a sliding bearing, a bearing seat and a bolt, wherein the power head is mounted and fixed on the regulating base, the regulating base is mounted and fixed on the sliding worktable through the bolt and the circular arc-shaped slotted holes which are in bilateral symmetry on the regulating base, the sliding worktable is mounted and fixed on the two upright posts through the sliding bearing and the bearing seat, the upright posts are mounted and fixed on the base, the upper cross beam is mounted and fixed at the upper end parts of the upright posts, the lower end of the lead screw is connected with the sliding worktable in a threaded fit manner, the upper end of the lead screw is connected with the upper cross beam, and the top end of the lead screw and the handwheel are connected and fixed.