The invention relates to a three-way adjusting, mounting and fixing device of vehicle-mounted navigation equipment. The device comprises a panel assembly, a moving assembly, a host assembly and a cabinet barrel; the moving assembly is arranged on one side of the panel assembly; the host assembly is arranged on the moving assembly and located on the side, away from the panel assembly, of the movingassembly; the cabinet barrel is arranged on the periphery of the host assembly; and the side, facing the moving assembly, of the cabinet barrel is connected with the moving assembly; the panel assembly comprises a decorative ring, a touch screen, a panel, an LCD liquid crystal module, an LCD support, a TFT _ PCB and a shell; the moving assembly comprises an installation plate, a push rod, a pressing plate, a guide column, a first reset spring, a sliding support, a torsion rotating shaft bolt assembly, a host installation support, a decorative shield, a decorative cover, a cabinet barrel positioning assembly and an adjusting assembly; and the adjusting assembly comprises a rotating support, a third reset spring, a movable tooth-shaped stop buckle and a tooth-shaped stop buckle. The up-down, front-back and angle positions of the display screen can be manually adjusted, a host structure does not need to be replaced, and disassembly and assembly are simple.