The invention discloses special main bearing sealing grease for a shield tunneling machine. According to the formula, the special main bearing sealing grease is prepared from the ingredients, in percentage by weight: 8-16% of base oil, 2-5% of thickener, 10-20% of fire retardant, 15-25% of tackifier, 12-20% of lubricating agent, 4-8% of reinforcing agent, 20-30% of filler, 0.5-3% of antiwear agent, 1-3% of antirust agent and 0.5-1% of antioxidant. The invention further provides a preparation method of the special main bearing sealing grease for the shield tunneling machine. The special main bearing sealing grease for the shield tunneling machine can resist the water pressure as high as 3.5MPa at the temperature of 25 DEG C in a lab, and has good water pressure resistance and airtightness.The pumping property of the special main bearing sealing grease is 30-60g/min at the temperature of -5-40 DEG C and under the pressure of 1MPa, the pumping property is excellent and not affected by the environmental temperature, and thus the construction problems that the pumping property in winter is poor, and pipes are blocked and the like. In addition, the product has the outstanding fire resistance, abrasive resistance and demulsibility.