The invention discloses a control method of a printing machine with a heat dissipation assembly. A temperature sensor detects the temperature of the printing machine, a control element receives the temperature of the printing machine, when a received temperature value detected by the temperature sensor is less than a first threshold value, the control element controls a ventilation valve to be opened, when a cooling fan does not work, an adjusting plate completely seals cooling holes, a first control valve and a second control valve are closed, an air feeder is closed, the ventilation valve achieves air connection of the whole device, cooling is achieved through an outer shell and a channel material, after printing is finished, a controller controls the cooling fan to continue working forpreset time, the ventilation valve is closed, the cooling holes are completely closed, the first control valve is closed, the second control valve is opened, and when a pressure signal of the pressuresensor does not reduced any more, the cooling fan is closed and the second control valve is closed.