The invention relates to a beta-1, 3 / alpha-1, 3-
glucan nanofiber and a preparation method and application thereof.The preparation method comprises the steps that 5.5 wt%-6.5 wt% of a
drug carrier and 10 wt%-20 wt% of beta-1, 3 / alpha-1, 3-
glucan are added into a pre-prepared
solution system at the same time and stirred and mixed, and an electrostatic
spinning solution is obtained; and performing electrostatic
spinning processing on the electrostatic
spinning solution by adopting an electrostatic spinning process to obtain the beta-1, 3 / alpha-1, 3-
glucan nanofiber. The beta-1, 3 / alpha-1, 3-glucan
nanofiber prepared by the method has better water
solubility, good
dispersity and better anti-inflammatory and antibacterial curative effects; meanwhile,
polycaprolactone which is good in
biocompatibility, free of
immunogenicity, biodegradable and high in
mechanical strength is selected as a base material of the nanofiber, so that the beta-1, 3 / alpha-1, 3-glucan nanofiber is high in mechanical performance and good in compatibility; and by controlling the parameters of the electrostatic spinning process, the
diameter and the form of the nanofiber can be accurately controlled, no particle
crosstalk state exists, and different application requirements can be met.