74results about How to "Reduce propensity" patented technology

This relates to a device for treating lung disease, and more particularly, relates to a device for exchanging energy with airway tissue such as that found in the airways of human lungs. The exchange of energy with this airway tissue in the airways reduces the ability of the airways to constrict and/or reduces the resistance within the airway to the flow of air through the airway.

A method for making a wound dressing having an absorbent core includes the steps of inserting a plurality of projection elements into a distal surface of the absorbent core such that the projection elements extend into a thickness of the absorbent core and are suitably heated to impart their shape in the absorbent core. The projection elements are removed from the absorbent core to form receptacles therein. A discrete portion of at least one absorbent material is inserted in each of the receptacles.

The present invention provides systems and methods for managing intake of a pharmacological agent. In one method of the present invention, the systems and methods are for controlling intake of an anti-epileptic drug. In such embodiments, one or more signals from a patient are processed to predict an onset of a seizure. Upon the prediction of the seizure, the patient is allowed to access the pharmacological agent in a pharmacological agent dispenser.

Systems and methods for reducing distention in designated portions of a heart muscle while assisting cardiac valve alignment and coaptation. Anchoring devices are secured to the heart muscle and a bio-compatible cardiac assist device placed over portions of the heart muscle is separately secured to the anchoring devices. The cardiac assist device may be a material that wraps portions of the heart muscle, or may be straps that wrap portions of the heart muscle. Tightening and securing the cardiac assist device in place helps to reduce distention in chambers of the heart muscle and aids alignment and coaptation of cardiac valves.

A smoking article having one or more reconstituted tobacco split inner wrap strips is described. One or more split inner wrap strips extend coaxially along the tobacco column between the inner surface of an outer wrap of cigarette paper and the tobacco column. The tobacco blend includes burley and a second tobacco, such as flue-cured, oriental, Maryland, or rare and exotic tobaccos, and combinations thereof. This blend improves burley smoke character without increasing Hoffman analyte levels, especially tobacco-specific nitrosamines (i.e., TNSAs). A cigarette with an improved burley smoke character without increasing Hoffman analyte levels is also described.

The present invention provides a smoking article having a reduced ignition propensity by reason of one or more cross-directional bands of an adhesive applied to the paper wrapper of the smoking article. The adhesive may be one of a cigarette seam adhesive, a filter plug wrap adhesive or a tipping paper adhesive conventionally used in the manufacture of cigarettes. A cigarette maker is modified to include the adhesive applicator apparatus of the invention which applies the adhesive bands to the paper wrapper in an in line process.

A reconstituted tobacco sheet for use in a cigarette includes up to about 80% by weight of wood pulp, up to about 30% by weight of a binder, and up to about 80% by weight of tobacco. A humectant and a flavor may be included. The reconstituted tobacco sheet is used in elongated strips along the outer surface of a tobacco rod between the tobacco rod and an inner surface of an outer wrap of cigarette paper

Cigarettes are manufactured using modified automated cigarette making apparatus. Those cigarettes possess smokable rods having wrapping paper having additive materials applied thereto as patterns. The additive materials, which can include a starch and/or a polymer, are applied to a continuous paper web either online or offline the cigarette making apparatus. The formulation can be applied to the paper web using application apparatus possessing a series of rollers. In particular, a wrapping paper for a smokable rod can include a pattern of bands having a water-insoluble material comprising a starch ester, a starch-coated inorganic filler, and/or a thermoplastic polymer in an amount such that the material is sufficiently deformable so as to (a) reduce an amount of pressure to apply the bands, (b) decrease paper diffusivity, and (c) maintain paper opacity at a level acceptable for commercial production of the smokable rods.

A button head tie has a button head and a tie strap. The button head is a generally flat member having an aperture for receiving the tie strap. The aperture includes lead-in ramps to facilitate tie strap insertion and is configured to prevent angled tie strap insertion. The tie strap is a flat elongate member having a wedge that is captured within the aperture. The remainder of the strap passes through the aperture. The wedge and strap have teeth and serrations on both sides, respectively, the teeth and serrations being engageable. In use, the strap is looped around a bundle and inserted into the aperture to either side of the wedge. Strap insertion force is reduced by standoff tabs which elevate the wedge out of aperture, temporarily, during installation. When loop tension is applied to the bundle, the wedge is pulled into the aperture, compressively locking the strap.

The invention discloses a preparation method of a large-size aluminum alloy ingot, relating to a preparation method of aluminum alloy ingots, and the provided preparation method of a large-size aluminum alloy ingot solves the problem of easy cracking during preparing the large-size aluminum alloy ingots by the traditional aluminum alloy ingot preparation method. The method comprises the following steps of: spreading and scattering a NO. flux at the bottom of a smelting furnace; adding aluminum ingots, electrolytic copper, zinc ingots, aluminum-silicon intermediate alloy, aluminum-iron intermediate alloy, aluminum-manganese intermediate alloy, aluminum-chromium intermediate alloy and aluminum-titanium intermediate alloy into the smelting furnace and spreading and scattering a covering agent; heating to ensure that the materials are smelted, sequentially adding a zirconium composite salt and magnesium ingots as well as smelting and refining to obtain an aluminum alloy melt; filtering the aluminum alloy melt and then pouring into a crystallizer; and finally, obtaining the large-size aluminum alloy ingot through casting. The thickness of the ingot prepared by using the method is 500-600mm, the width is 1,600mm, and the length is 1,500-2,500mm. The ingot has no cracks, good surface quality and uniform internal grains, and the yield is not smaller than 65 percent.

The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides compositions or mixtures of antibodies capable of binding human EGFR. Antibody compositions with 3 or more antibodies shown synergy in reduction of proliferation of representative cancer cell lines. Advantageous results have also been obtained with a composition comprising two different chimeric anti-hEGFR antibodies which show a new mechanism of action based on rapid and efficient receptor internalisation, induction of terminal differentiation and subsequent tumour eradication in an animal model. The antibodies of the invention can be manufactured in one bioreactor as a polyclonal antibody.

An improved AM OLED pixel circuit and method of wide dynamic range dimming for AM OLED displays are disclosed that maintain color balance throughout the dimming range, and also maintain the uniformity of the luminance and chromaticity of the display at low gray-levels as the display is dimmed to lower luminance values. As such, AM OLED displays can meet the stringent color/dimming specifications required for existing and future avionics, cockpit, and hand-held military device display applications. Essentially, the OLED pixel circuit and method of dimming that are disclosed use Pulse Width Modulation (PWM) of the OLED pixel current to achieve the desired display luminance. Two example circuits are disclosed that externally PW modulate the common cathode voltage or common power supply voltage to modulate the OLED current in order to achieve the desired display luminance. Three example circuits are disclosed that incorporate additional transistor switches in the pixel circuit to modulate the OLED current during the frame time. By PWM of the OLED current, in combination with data voltage (or current) modulation, wide dynamic range dimming can be achieved while maintaining the color balance and the luminance and chromaticity uniformity required over the surface of the display involved.

The invention discloses a preparation method of a large-size aluminum alloy ingot, relating to a preparation method of aluminum alloy ingots and solving the problems of easy cracking and difficult forming during preparing the large-size aluminum alloy ingots by the traditional aluminum alloy ingot preparation method. The method comprises the following steps of: spreading and scattering a NO.1 flux at the bottom of a smelting furnace; adding aluminum ingots, electrolytic copper, zinc ingots, aluminum-silicon intermediate alloy, aluminum-iron intermediate alloy, aluminum-manganese intermediate alloy, aluminum-chromium intermediate alloy and aluminum-titanium intermediate alloy into the smelting furnace and spreading and scattering a covering agent; heating to ensure that the materials in the smelting furnace are smelted; adding magnesium ingots and then smelting; then refining to obtain an aluminum alloy melt; filtering the aluminum alloy melt and then pouring into a crystallizer; and finally, obtaining the large-size aluminum alloy ingot through casting. The thickness of the prepared ingot is 500-600mm, the width is 600mm, and the length is 2,000-3,500mm. The ingot has no cracks, good surface quality and uniform internal grains, and the yield is not smaller than 90.5 percent.

CRF₁ receptor antagonists have the potential to directly inhibit ACTH release in patients with CAH and thereby allow normalization of androgen production while using lower, more physiologic doses of hydrocortisone, and thus reducing treatment-associated side effects.

A brake disc arrangement has a mounting portion formed of a metal, with a plurality of radial protuberances extending radially outward therefrom. The radial protuberances each have a radially distal tip portion, and a ceramic coating is applied to the radially distal tip portion of the radial protuberances. The brake plate portion is cast so as to surround the radially distal tip portions. However, it is isolated therefrom by the ceramic coating. At least some of the radially distal tip portions are formed of metal having a microstructure created by electrical discharge machining to increase dampening. A sand core within a core box holds the mounting portion in a predetermined fixed orientation. The molten metal is poured into the core box mold, and the metal brake plate portion is prevented by the ceramic coating from welding to any of the plurality of radial protuberances.

A method and system for determining particle size distribution and/or filterable solids in bitumen-containing fluid is described. A sample of bitumen-containing fluid, such as bitumen-froth feed, bitumen-froth solvent or paraffinic-froth-treated (PFT) bitumen-solvent is obtained. An optimized diluent combination is determined, comprising an aromatic or cycloaliphatic solvent such as toluene, benzene, naphthalene, xylene, anthracene, or cyclohexane together with a C3 to C12 paraffinic solvent. The combination is considered optimized when diluting the sample with the combination maintains substantially the same level of deasphalting in the diluted sample as in the undiluted sample. Upon dilution of the sample with optimized diluent combination, particle size distribution can be accurately determined using optical instrumentation, laser diffraction instrumentation, electrical counting instrumentation, or ultrasonic instrumentation.

The invention relates to a rare earth aluminum alloy and a preparation method thereof, and belongs to the technical field of alloy synthesis. The rare earth aluminum alloy is prepared through vacuum suction casting of an aluminum basal body and a rare earth source; and the rare earth aluminum alloy is obtained by performing primary smelting on the aluminum basal body, refining, adding the rare earth source into a refined product, and performing impurity removal for vacuum suction casting molding. The rare earth aluminum alloy is applied to the processing of rare earth aluminum alloys and radiator section bars, and has such advantages as high compactness, good wear resistance, good weldability and high heat conductivity.

Fouling in a dispersed phase reactor in the presence of a phosphinimine catalyst and MAO may be reduced by reducing the loading of the phosphinimine catalyst to provide from 0.02 to 0.031 mmol of transition M per g of catalyst while still maintaining a productivity of not less than 2500 g of polymer/gram of catalyst. The catalyst may optionally be used in the presence of an antistatic agent.

Fire-retardant, heat-resistant, smoke-suppressant plastic materials, such as polyvinyl chloride, having incorporated therein an intumescent material are disclosed. The intumescent material comprise and intumescent catalyst selected from the group consisting of salts of phosphoric acid and salts of sulfuric acid; and a carbonific material selected from the group consisting of starches, sugars, sugar alcohols, oils, and plasticizers. The fire-retardant, heat-resistant, smoke-suppressant plastic materials may be in the form of a foamed or non-foamed plastic. Methods of making such plastic materials are also disclosed.

A low ignition propensity cigarette paper includes base cigarette paper having a basis weight exceeding 22 g/m², and a plurality of burn limiting areas arranged apart from one another on one surface of the base cigarette paper. The burn limiting areas are formed by applying sodium alginate having a degree of polymerization of about 500 to about 900 or sodium alginate whose 3% by weight aqueous solution exhibits a viscosity of 19000 cP or more as measured at 25° C.

The present invention provides indoline heterocyclic compounds of the following formula I:

or pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof useful as antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.

The invention discloses a method for determing a normal acceleration (az), a longitudinal angular acceleration (ax) and a lateral angular acceleration (ay) of a body, especially a motor vehicle. The body comprises a longitudinal rotation axis (x), a lateral rotation axis (y), at least three spring elements (5), at least three shock absorbers (6) and at least three height sensors (7) with each height sensor (7) being disposed in the area of corresponding sensor (6). The method is characterized in that the damping force (FDi) of the shock absorbers (6), the spring force (FSi) of the spring elements (5), the gravity center of the body, the mass of the body (mB), the moment of inertia of the body (Jxx, Jyy), the positions of the shock absorbers with respect to the body (sv, sh, Iv, Ih), the average height (hx) of the longitudinal rotation axis and the average height (hy) of the lateral rotation axis are determined; The normal acceleration (az), the longitudinal angular acceleration (ax) and the lateral angular acceleration (ay) are determined by means of the mass of the body (mB), the moment of inertia of the body (Jxx, Jyy), the positions of the shock absorbers with respect to the body (sv, sh, Iv, Ih), the average height (hx) of the longitudinal rotation axis and the average height (hy) of the lateral rotation axis, the damping force (FDi) of the shock absorbers (6), and the spring force (FSi) of the spring elements (5).