The invention provides an AMOLED pixel drive circuit, a drive method and an array drive system. The AMOLED pixel drive circuit comprises a first transistor, a second transistor, an organic light emitting diode and a drive transistor, wherein a threshold voltage of the drive transistor can be adjusted. The grid of the first transistor is connected with a first scanning signal, the first electrode of the first transistor is connected with a grid voltage signal, and the second electrode of the first transistor is connected with a control grid of the drive transistor. The source of the drive transistor is connected to the ground, and the drain of the drive transistor is connected with the first pole of the organic light emitting diode. The second pole of the organic light emitting diode is connected with an external power source. The grid of the second transistor is connected with a second scanning signal, the first electrode of the second transistor is connected with a data signal, and the second electrode of the second transistor is connected with the first pole of the organic light emitting diode. According to the AMOLED pixel drive circuit, a traditional capacitor and a PMOS transistor are replaced by the drive transistor with the adjustable threshold voltage. Therefore, the relative aperture of pixel structures is greatly improved, and light-emitting efficiency of the pixel structures is greatly improved.