The invention discloses health-care sesame oil capable of maintaining beauty and keeping young and a preparation method thereof. The health-care sesame oil is characterized by being prepared from the following raw materials in parts by weight: 1350-1400 parts of sesame, 35-45 parts of almonds, 10-15 parts of sunflower seeds, 5-7 parts of hippophae rhamnoides leaves, 1-2 parts of red clover grass, 1-2 parts of Chinese roses, 1-2 parts of peach flowers, 1-2 parts of glossy privet fruits, 1-2 parts of bryophyllum pinnatum, and 2-4 parts of dendrobium. Besides the sesame, the raw materials, such as the hippophae rhamnoides leaves, the red clover grass, the Chinese roses and the peach flowers, which can maintain beauty and keep young and clear heat and remove toxicity, are added into the health-care sesame oil, so that the edible value of the sesame oil is increased, and the health-care sesame oil, disclosed by the invention, has unique dietetic therapy and health-care effects; in a production process of the health-care sesame oil, an environmentally-friendly high-efficient supercritical carbon dioxide fluid extraction technology is adopted, so that the nutrient components in the raw materials are furthest protected. The health-care sesame oil disclosed by the invention is rich in fragrance and clear and transparent, and is particularly suitable for daily health care of female consumers.