The invention discloses a pesticide composition containing cycloxaprid and pyrethroids. The composition is mainly characterized by containing an active ingredient A, an active ingredient B and the balance of auxiliaries, wherein the active ingredient A is cycloxaprid; the active ingredient B is any one of ethofenprox, bifenthrin, lambda-cyhalothrin, fenvalerate, beta-cyfluthrin, deltamethrin and fenpropathrin; and the weight ratio of the active ingredient A to the active ingredient B is (60:1)-(1:60). The composition can be prepared into wettable powder, water dispersible granules, emulsifiable solution, suspensions, suspoemulsion, emulsion in water, microemulsion, microcapsule suspensions and microcapsule-microcapsule suspensions. The composition can be used for controlling various diseases, has obvious synergistic effect, expands the pesticidal spectrum, has higher activity against the pests on rice, wheat, cruciferous vegetables, tea trees, cotton and fruit trees, has slow release effect, reduces the pesticide application quantity, is harmless to people and livestock, has no phytotoxicity and has good environmental compatibility. The preparations have the advantages of enhanced adhesive forces, rain wash resistance, long duration of efficacy and the like.